SCHEMBL4758577

SCHEMBL4758577

CCN1C(C)=C(C(=O)O)C(CC)(c2cccc(Cl)c2Cl)C(C(=O)O)=C1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.36
PYGL P06737 6/20 0.35
PYGM P11217 6/20 0.35
NOTUM Q6P988 2/20 0.35
KMT2A Q03164 3/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
ALDH1A1 P00352 2/20 0.34
GAA P10253 2/20 0.34
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
P2RX7 Q99572 1/20 0.32
TAS1R3 Q7RTX0 1/20 0.32
TAS1R1 Q7RTX1 1/20 0.32
TAS1R2 Q8TE23 1/20 0.32
SLC22A12 Q96S37 1/20 0.32
CYP2C9 P11712 4/20 0.32
ERCC5 P28715 1/20 0.31
FEN1 P39748 1/20 0.31
LMNA P02545 2/20 0.31
KDM4E B2RXH2 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4757355 0.90 PYGM (0.39) PYGLPYGMNOTUMALDH1A1GAA
SCHEMBL9101372 0.88 TSHR (0.37) TSHRNOTUMKMT2AL3MBTL1ALDH1A1
SCHEMBL4758583 0.87 PYGL (0.38) TSHRPYGLPYGMNOTUMKMT2A
SCHEMBL2365028 0.86 TSHR (0.37) TSHRPYGLPYGMNOTUMKMT2A
SCHEMBL4757320 0.80 HCAR2 (0.39) TSHRNOTUMALDH1A1GAALMNA
SCHEMBL4758286 0.80 TSHR (0.36) TSHRNOTUML3MBTL1ALDH1A1CRHBP
SCHEMBL4756152 0.79 LMNA (0.33) PYGLPYGMKMT2AALDH1A1CYP2C9
SCHEMBL4755316 0.79 HCAR2 (0.36) TSHRPYGLPYGMNOTUMKMT2A
SCHEMBL4089394 0.78 APP (0.41) KMT2AALDH1A1LMNAMEN1
SCHEMBL7289569 0.77 BACE1 (0.36) ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012123966-A1 PROCESS FOR THE PREPARATION OF 4 -SUBSTITUTED -1, 4-DIHYDROPYRIDINES ARCH PHARMALABS LIMITED (IN) 2012-09-20 WO disclosed
WO-2008006070-A2 COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF ROSKAMP RESEARCH LLC (US) 2008-01-10 WO disclosed
EP-1858325-A2 COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS Roskamp Research LLC (US) 2007-11-28 EP disclosed
WO-2006074419-A2 COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS ROSKAMP RESEARCH LLC (US) 2006-07-13 WO disclosed