Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4885125 | 1.00 | TRPM8 (0.62) | TRPM8NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL4881344 | 0.91 | RAB9A (0.57) | TRPM8NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL4881351 | 0.91 | RAB9A (0.57) | TRPM8NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL14148791 | 0.90 | L3MBTL1 (0.61) | TRPM8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29407319 | 0.90 | L3MBTL1 (0.61) | TRPM8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14148789 | 0.90 | L3MBTL1 (0.57) | TRPM8SMN1; SMN2MAPT | |
| SCHEMBL17340457 | 0.83 | GABRA1 (0.57) | GABRA1GABRB2GABRG2GABRB3GABRA3 | |
| SCHEMBL28418448 | 0.81 | TRPM8 (0.72) | TRPM8NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL31547842 | 0.81 | TRPM8 (0.72) | TRPM8NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL15219985 | 0.79 | CYP3A4 (0.56) | TRPM8RAB9ASMN1; SMN2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9894921-B2 | Use of cinnamic acid derivatives containing nitrogen as flavouring agents | SYMRISE AG (DE) | 2018-02-20 | — | — | US | disclosed |
| US-9894921-B2 | Use of cinnamic acid derivatives containing nitrogen as flavouring agents | SYMRISE AG (DE) | 2018-02-20 | — | — | US | disclosed |
| EP-2737807-B1 | Use of nitrogen-containing derivatives of cinnamic acid as flavourants | SYMRISE AG (DE) | 2017-04-05 | — | — | EP | disclosed |
| US-20150272185-A1 | USE OF CINNAMIC ACID DERIVATIVES CONTAINING NITROGEN AS FLAVOURING AGENTS | SYMRISE AG (DE) | 2015-10-01 | — | — | US | disclosed |
| US-20150272185-A1 | USE OF CINNAMIC ACID DERIVATIVES CONTAINING NITROGEN AS FLAVOURING AGENTS | SYMRISE AG (DE) | 2015-10-01 | — | — | US | disclosed |
| US-9144248-B2 | Cinnamamides as savory flavorings | SYMRISE AG (DE) | 2015-09-29 | — | — | US | disclosed |
| US-9144248-B2 | Cinnamamides as savory flavorings | SYMRISE AG (DE) | 2015-09-29 | — | — | US | disclosed |
| EP-2737807-A1 | Use of nitrogen-containing derivatives of cinnamic acid as flavourants | Symrise AG (DE) | 2014-06-04 | — | — | EP | disclosed |
| EP-2529632-B1 | Cinnamic acid amides as spicy flavour agents | SYMRISE AG (DE) | 2013-08-28 | — | — | EP | disclosed |
| US-20120308703-A1 | Cinnamamides as savory flavorings | SYMRISE AG (DE) | 2012-12-06 | — | — | US | disclosed |
| US-20120308703-A1 | Cinnamamides as savory flavorings | SYMRISE AG (DE) | 2012-12-06 | — | — | US | disclosed |
| EP-2529632-A1 | Cinnamic acid amides as spicy flavour agents | Symrise AG (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-20080038386-A1 | Use of a liquid cooling sensate to provide a pungent, warming or tingling sensate composition | MOZA ASHOK K | 2008-02-14 | — | — | US | disclosed |