Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886782 | 0.92 | LMNA (0.58) | LMNASMN1; SMN2ALDH1A1GAASERPINE1 | |
| SCHEMBL4886798 | 0.82 | LMNA (0.56) | LMNASMN1; SMN2MMP1MMP9MMP13 | |
| SCHEMBL4894187 | 0.75 | PKM (0.49) | LMNASMN1; SMN2ALDH1A1MMP1MMP9 | |
| SCHEMBL4886776 | 0.74 | LMNA (0.67) | LMNASMN1; SMN2ALDH1A1GAAPOLB | |
| SCHEMBL4891235 | 0.74 | LMNA (0.41) | LMNASMN1; SMN2ALDH1A1MMP1MMP9 | |
| SCHEMBL4895346 | 0.73 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1MMP1MMP9 | |
| SCHEMBL3440426 | 0.71 | BDKRB1 (0.52) | — | |
| SCHEMBL5216887 | 0.69 | ALDH1A1 (0.55) | LMNASMN1; SMN2ALDH1A1GAAPOLB | |
| SCHEMBL4894694 | 0.68 | LMNA (0.53) | LMNASMN1; SMN2ALDH1A1GAAMMP1 | |
| SCHEMBL26769715 | 0.67 | LMNA (0.64) | LMNASMN1; SMN2ALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008518889-A | — | — | 2008-06-05 | — | — | JP | claimed |
| EP-1812405-A1 | NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-01 | — | — | EP | claimed |
| WO-2006048209-A1 | NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-05-11 | — | — | WO | claimed |