Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MMP13 | P45452 | 7/20 | 0.52 |
| ▸ | MMP1 | P03956 | 6/20 | 0.52 |
| ▸ | MMP9 | P14780 | 4/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 6/20 | 0.51 |
| ▸ | MMP14 | P50281 | 5/20 | 0.51 |
| ▸ | MMP8 | P22894 | 3/20 | 0.51 |
| ▸ | MMP16 | P51512 | 2/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.50 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886798 | 0.81 | LMNA (0.56) | LMNAMMP13MMP1MMP9ADAM17 | |
| SCHEMBL6324820 | 0.74 | LMNA (0.62) | LMNAMMP13MMP1MMP9ADAM17 | |
| SCHEMBL14056017 | 0.74 | TGM2 (0.57) | LMNAMMP13MMP1MMP9HTT | |
| SCHEMBL4886776 | 0.73 | LMNA (0.67) | LMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4891235 | 0.73 | LMNA (0.41) | LMNAMMP13MMP1MMP9ADAM17 | |
| SCHEMBL4886802 | 0.73 | LMNA (0.48) | LMNAMMP13MMP1MMP9ADAM17 | |
| SCHEMBL13898783 | 0.72 | MEP1B (0.63) | MMP13MMP1MMP9MMP2MMP14 | |
| SCHEMBL5216887 | 0.71 | ALDH1A1 (0.55) | LMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL6320959 | 0.70 | ADAM17 (0.61) | LMNAMMP13MMP1MMP9ADAM17 | |
| SCHEMBL13898736 | 0.70 | BMP1 (0.48) | MMP13MMP1MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008518889-A | — | — | 2008-06-05 | — | — | JP | claimed |
| EP-1812405-A1 | NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-01 | — | — | EP | claimed |
| WO-2006048209-A1 | NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-05-11 | — | — | WO | claimed |