Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | GCK | P35557 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602994 | 0.84 | MAPT (0.59) | SMN1; SMN2L3MBTL1ADORA3NPC1RAB9A | |
| SCHEMBL15426988 | 0.84 | GCK (0.69) | SMN1; SMN2TAS1R3TAS1R1TAS1R2GCK | |
| SCHEMBL14270047 | 0.83 | LMNA (0.67) | SMN1; SMN2L3MBTL1NPC1RAB9AMAPT | |
| SCHEMBL15867678 | 0.82 | SCD (0.65) | ABL1ADORA3NPC1RAB9AMAPT | |
| SCHEMBL3604622 | 0.81 | KDM4E (0.59) | SMN1; SMN2L3MBTL1NPC1RAB9AMAPT | |
| SCHEMBL4891680 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3602131 | 0.80 | GCK (0.58) | SMN1; SMN2L3MBTL1GCKGRM5NPC1 | |
| Hydrochloric Acid SCHEMBL4890437 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6799313 | 0.78 | RAB9A (0.60) | SMN1; SMN2L3MBTL1GCKNPC1RAB9A | |
| SCHEMBL15427051 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2TAS1R3TAS1R1TAS1R2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039499-A1 | Chemical Compounds | BOWER JUSTIN F | 2008-02-14 | — | — | US | disclosed |
| US-20080039499-A1 | Chemical Compounds | BOWER JUSTIN F | 2008-02-14 | — | — | US | disclosed |
| US-20080039499-A1 | Chemical Compounds | BOWER JUSTIN F | 2008-02-14 | — | — | US | disclosed |
| CN-1993358-A | Thiazole derivatives as chemokine receptor antagonists | ASTRAZENECA AB (SE) | 2007-07-04 | — | — | CN | disclosed |
| EP-1761526-A2 | THIAZOLE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005118579-A2 | THIAZOLE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039499-A1 | Chemical Compounds | CCR1, CCL11, CXCR1 | SMN1; SMN2 4200/4885TAS1R3 1289/4885TAS1R1 1058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.