Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HEXA | P06865 | 1/20 | 0.42 |
| ▸ | HEXB | P07686 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487894 | 0.96 | ACHE (0.46) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL20809931 | 0.96 | CNR1 (0.49) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL12415344 | 0.90 | L3MBTL1 (0.45) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL9612423 | 0.90 | MAPK1 (0.43) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL25656537 | 0.90 | RAB9A (0.46) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL18904909 | 0.90 | CNR1 (0.41) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL8853507 | 0.88 | RAB9A (0.43) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL27930163 | 0.87 | ALOX5 (0.52) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL25957704 | 0.87 | ENPP1 (0.44) | ACHECNR1CNR2RAB9ATSHR | |
| SCHEMBL12245639 | 0.87 | ACHE (0.50) | ACHECNR1CNR2RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8105836-B2 | Chemical inhibitors of mismatch repair | MORPHOTEK, INC. (US) | 2012-01-31 | — | — | US | claimed |
| EP-1351565-B1 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | MORPHOTEK INC (US) | 2011-03-16 | — | — | EP | claimed |
| US-6982169-B2 | Chemical inhibitors of mismatch repair | MORPHOTEK, INC. (US) | 2006-01-03 | — | — | US | claimed |
| EP-1351565-A4 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | MORPHOTEK INC (US) | 2005-05-25 | — | — | EP | claimed |
| EP-1417329-A4 | METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS | MORPHOTEK INC (US) | 2005-05-11 | — | — | EP | claimed |
| EP-1417329-A1 | METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS | Morphotek Inc. (US) | 2004-05-12 | — | — | EP | claimed |
| EP-1351565-A1 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | Morphotek Inc. (US) | 2003-10-15 | — | — | EP | claimed |
| US-20030143586-A1 | Genetic hypermutability of plants for gene discovery and diagnosis | MORPHOTEK, INC. | 2003-07-31 | — | — | US | claimed |
| US-20030091997-A1 | Chemical inhibitors of mismatch repair | EISAI, INC. | 2003-05-15 | — | — | US | claimed |
| WO-2003031937-A2 | GENETIC HYPERMUTABILITY OF PLANTS FOR GENE DISCOVERY AND DIAGNOSIS | MORPHOTEK, INC. (US) | 2003-04-17 | — | — | WO | claimed |
| US-20030068808-A1 | Methods for generating antibiotic resistant microbes and novel antibiotics | MORPHOTEK, INC. | 2003-04-10 | — | — | US | claimed |
| WO-2003012130-A1 | METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS | MORPHOTEK INC. (US) | 2003-02-13 | — | — | WO | claimed |
| WO-2002054856-A1 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | MORPHOTEK INC. (US) | 2002-07-18 | — | — | WO | claimed |
| US-10023632-B2 | Antigenic GM-CSF peptides and antibodies to GM-CSF | MORPHOTEK, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| EP-3181585-A2 | ANTIGENIC GM-CSF PEPTIDES AND ANTIBODIES TO GM-CSF | Morphotek, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| US-20160333089-A1 | Antigenic GM-CSF Peptides and Antibodies to GM-CSF | EISAI, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20030068808-A1 | Methods for generating antibiotic resistant microbes and novel antibiotics | MORPHOTEK, INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2003012130-A1 | METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS | MORPHOTEK INC. (US) | 2003-02-13 | — | — | WO | disclosed |
| US-20020192497-A1 | Electroluminance device | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2002-12-19 | — | — | US | disclosed |
| WO-2002054856-A1 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | MORPHOTEK INC. (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160333089-A1 | Antigenic GM-CSF Peptides and Antibodies to GM-CSF | CSF3R, CSF1R, GMFG | ACHE 3462/4885CNR1 4544/4885CNR2 4674/4885 |
| US-10023632-B2 | Antigenic GM-CSF peptides and antibodies to GM-CSF | CSF3R, CSF1R, GMFG | ACHE 3462/4885CNR1 4544/4885CNR2 4674/4885 |
| US-20030091997-A1 | Chemical inhibitors of mismatch repair | MSH2, MSH6, PMS2 | ACHE 3887/4885CNR1 4534/4885CNR2 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.