Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708661 | 0.88 | HTR6 (0.46) | BACE1HTR6GRIN2BMAPTALDH1A1 | |
| SCHEMBL4887610 | 0.81 | BACE1 (0.51) | BACE1ACHEMEN1KMT2AMAPT | |
| SCHEMBL4172924 | 0.81 | PARP1 (0.49) | BACE1HTR6ACHEPARP1MAPT | |
| SCHEMBL4899723 | 0.80 | PARP1 (0.54) | HTR6ACHEPARP1KIT | |
| SCHEMBL4887206 | 0.79 | BACE1 (0.51) | BACE1ACHEMEN1KMT2AMAPT | |
| SCHEMBL10004541 | 0.75 | PARP1 (0.55) | BACE1HTR6PARP1MAPTKIT | |
| SCHEMBL23508272 | 0.75 | TNKS (0.46) | MAPTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4887144 | 0.74 | RIPK1 (0.47) | MAPTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18751212 | 0.73 | SIGMAR1 (0.60) | BACE1MEN1KMT2AP2RX7 | |
| SCHEMBL3049200 | 0.73 | SIGMAR1 (0.60) | BACE1MEN1KMT2AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214562-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
| US-20080045537-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-02-21 | — | — | US | disclosed |
| EP-1789045-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006023400-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214562-A1 | Chemical Compounds | CCR5, CXCR4, CXCR3 | BACE1 1860/4885HTR6 2506/4885ACHE 4784/4885 |
| US-20080045537-A1 | Chemical Compounds | CCR5, CXCR4, CXCR3 | BACE1 1868/4885HTR6 2334/4885ACHE 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.