Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GNRHR | P30968 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4172924 | 0.87 | PARP1 (0.49) | PARP1HTR6MAP4K4KITCKS1B | |
| SCHEMBL10004541 | 0.84 | PARP1 (0.55) | PARP1HTR6MAP4K4KITSMARCA2 | |
| SCHEMBL4889402 | 0.80 | BACE1 (0.49) | PARP1HTR6KITACHE | |
| SCHEMBL13324606 | 0.78 | GNRHR (0.65) | GNRHR | |
| SCHEMBL29337387 | 0.77 | DRD2 (0.51) | PARP1MAP4K4KITSMARCA2SMARCA4 | |
| SCHEMBL110163 | 0.74 | NCF1 (0.51) | KITSMARCA2SMARCA4PBRM1CKS1B | |
| SCHEMBL3673763 | 0.74 | TRPV1 (0.53) | PARP1KITSMARCA2SMARCA4PBRM1 | |
| SCHEMBL23629118 | 0.74 | SMARCA2 (0.51) | MAP4K4KITSMARCA2SMARCA4PBRM1 | |
| SCHEMBL1048457 | 0.74 | POLB (0.55) | MAP4K4SMARCA2SMARCA4PBRM1CKS1B | |
| SCHEMBL1537800 | 0.73 | CKS1B (0.50) | PARP1MAP4K4KITSMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214562-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214562-A1 | Chemical Compounds | CCR5, CXCR4, CXCR3 | PARP1 1231/4885HTR6 2506/4885MAP4K4 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.