Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896033 | 1.00 | TP53 (0.41) | TP53MAPK10MAPTALDH1A1HTT | |
| SCHEMBL14020631 | 1.00 | TP53 (0.41) | TP53MAPK10MAPTALDH1A1HTT | |
| SCHEMBL4095153 | 0.75 | ALDH1A1 (0.44) | TP53MAPK10MAPTALDH1A1HTT | |
| SCHEMBL4092695 | 0.75 | ALDH1A1 (0.43) | TP53MAPK10MAPTALDH1A1HTT | |
| SCHEMBL4095154 | 0.75 | ALDH1A1 (0.44) | TP53MAPK10MAPTALDH1A1HTT | |
| SCHEMBL4104086 | 0.75 | ALDH1A1 (0.43) | TP53MAPK10MAPTALDH1A1HTT | |
| SCHEMBL28964283 | 0.74 | ALDH1A1 (0.41) | TP53MAPK10MAPTALDH1A1GAA | |
| Potassium Ion SCHEMBL23930585 | 0.72 | ALDH1A1 (0.40) | TP53MAPK10MAPTALDH1A1GAA | |
| Potassium Ion SCHEMBL23930588 | 0.72 | ALDH1A1 (0.40) | TP53MAPK10MAPTALDH1A1GAA | |
| SCHEMBL17238089 | 0.72 | ALDH1A1 (0.40) | TP53MAPK10MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262064-A1 | Novel Compounds For The Treatment Of GI Disorders 682 | ASTRAZENECA AB (SE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262064-A1 | Novel Compounds For The Treatment Of GI Disorders 682 | GABRB2, GABRA2, GABBR2 | TP53 4858/4885MAPK10 2744/4885MAPT 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.