Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4095153 | 1.00 | ALDH1A1 (0.44) | ALDH1A1MAOAMAOBMEN1KMT2A | |
| SCHEMBL4500748 | 0.80 | FAAH (0.41) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4500750 | 0.80 | FAAH (0.41) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL14257545 | 0.80 | FAAH (0.41) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4104086 | 0.76 | ALDH1A1 (0.43) | ALDH1A1MAOAMAOBMEN1KMT2A | |
| SCHEMBL4092695 | 0.76 | ALDH1A1 (0.43) | ALDH1A1MAOAMAOBMEN1KMT2A | |
| SCHEMBL28964283 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4896028 | 0.75 | TP53 (0.41) | ALDH1A1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL14020631 | 0.75 | TP53 (0.41) | ALDH1A1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL4896033 | 0.75 | TP53 (0.41) | ALDH1A1MEN1KMT2ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023704-A1 | Novel Compounds 737 | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | US | disclosed |
| US-20080262064-A1 | Novel Compounds For The Treatment Of GI Disorders 682 | ASTRAZENECA AB (SE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262064-A1 | Novel Compounds For The Treatment Of GI Disorders 682 | GABRB2, GABRA2, GABBR2 | ALDH1A1 2271/4885MAOA 1754/4885MAOB 1235/4885 |
| US-20090023704-A1 | Novel Compounds 737 | GRPR, GABRB1, GABBR1 | ALDH1A1 1248/4885MAOA 1399/4885MAOB 623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.