Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.64 |
| ▸ | CTSS | P25774 | 6/20 | 0.64 |
| ▸ | CTSB | P07858 | 5/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394484 | 1.00 | CTSK (0.64) | CTSKCTSSCTSBKCNH2ADAM10 | |
| SCHEMBL208853 | 0.85 | ADAM10 (0.77) | CTSKCTSSCTSBKCNH2ADAM10 | |
| SCHEMBL26706252 | 0.80 | MAPT (0.69) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL8115758 | 0.77 | CTSK (1.00) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL632109 | 0.75 | CA12 (0.69) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL16595411 | 0.74 | CA12 (0.67) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL16026460 | 0.73 | CA12 (0.71) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL27607283 | 0.73 | AKR1C3 (0.83) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL18500553 | 0.73 | MAPT (0.62) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL19214268 | 0.73 | SMN1; SMN2 (0.64) | CA12CA1CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234274-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| EP-1532124-B1 | Use of nitrile derivatives as medicament. | ASTRAZENECA AB (SE) | 2006-07-19 | — | — | EP | disclosed |
| US-20050245522-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234274-A1 | Novel Compounds | CTSS, CTSB, CTSF | CTSK 8/4885CTSS 1/4885CTSB 2/4885 |
| US-20050245522-A1 | Novel compounds | CTSS, CTSB, CTSF | CTSK 8/4885CTSS 1/4885CTSB 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.