Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.52 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | VPS4B | O75351 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | RB1 | P06400 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL833788 | 0.90 | HTR1B (0.65) | HTR1BHTR1DNR2E1SIGMAR1HTR6 | |
| SCHEMBL833781 | 0.90 | HTR1B (0.65) | HTR1BHTR1DNR2E1SIGMAR1HTR6 | |
| SCHEMBL833780 | 0.90 | HTR1B (0.65) | HTR1BHTR1DNR2E1SIGMAR1HTR6 | |
| SCHEMBL5792072 | 0.81 | SIGMAR1 (0.45) | SIGMAR1SIRT1BAZ2BDRD2SLC6A4 | |
| SCHEMBL5793567 | 0.80 | DRD2 (0.50) | SIGMAR1SIRT1BAZ2BDRD2SLC6A4 | |
| SCHEMBL11681778 | 0.79 | SIRT1 (0.57) | SIGMAR1SIRT1BAZ2BDRD2SLC6A4 | |
| SCHEMBL4905673 | 0.78 | NR2E1 (0.79) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL29992005 | 0.78 | NR2E1 (0.79) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL6533665 | 0.78 | NR2E1 (0.79) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL29991655 | 0.78 | NR2E1 (0.79) | HTR1BHTR1DNR2E1HTR6SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | disclosed |
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | disclosed |
| US-7297704-B2 | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | WYETH (US) | 2006-09-14 | — | — | US | disclosed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | TPH1, TPH2, HTR2C | HTR1B 19/4885HTR1D 18/4885NR2E1 775/4885 |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | TPH1, TPH2, HTR2C | HTR1B 19/4885HTR1D 18/4885NR2E1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.