Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891667 | 0.93 | HDAC2 (0.47) | KIF11HDAC2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7388602 | 0.89 | ALDH1A1 (0.47) | ALDH1A1HTTSMN1; SMN2KDM4EHDAC1 | |
| SCHEMBL4608553 | 0.84 | KIF11 (0.57) | KIF11HDAC2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4659870 | 0.77 | KIF11 (0.56) | KIF11KDM1A | |
| SCHEMBL25334235 | 0.76 | ALDH1A1 (0.47) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL5521041 | 0.75 | KIF11 (0.71) | KIF11KDM1A | |
| SCHEMBL25037396 | 0.75 | ACHE (0.57) | ALDH1A1KDM4EHDAC1HDAC8MEN1 | |
| SCHEMBL940712 | 0.75 | ALDH1A1 (0.52) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL30965893 | 0.75 | ALDH1A1 (0.67) | ALDH1A1HTTSMN1; SMN2KDM4EHDAC1 | |
| SCHEMBL25037265 | 0.75 | ALDH1A1 (0.67) | ALDH1A1HTTSMN1; SMN2KDM4EHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176830-A1 | Compounds, Compositions, and Methods | ADAMS NICHOLAS D | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176830-A1 | Compounds, Compositions, and Methods | ALPP, PCNA, MKI67 | KIF11 562/4885HDAC2 1216/4885ALDH1A1 2274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.