SCHEMBL4899752

SCHEMBL4899752

C[Si](C)(C)c1ccc2c(c1)-c1cc([Si](C)(C)C)ccc1C2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.35
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ACHE P22303 1/20 0.32
CHEK2 O96017 1/20 0.32
ROS1 P08922 1/20 0.32
MARK3 P27448 1/20 0.32
LTK P29376 1/20 0.32
FLT4 P35916 1/20 0.32
KDR P35968 1/20 0.32
MINK1 Q8N4C8 1/20 0.32
AURKB Q96GD4 1/20 0.32
PBK Q96KB5 1/20 0.32
STK17A Q9UEE5 1/20 0.32
MAP4K5 Q9Y4K4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25470451 0.94 MAPT (0.38) MAPTNPC1RAB9AKDM4EALDH1A1
SCHEMBL12879668 0.87
SCHEMBL4900031 0.86 RAB9A (0.42) MAPTNPC1RAB9AKDM4EALDH1A1
SCHEMBL8204767 0.80 BCHE (0.47) ACHEMETAP1MAOA
SCHEMBL4899827 0.79 NR1H2 (0.39) MAPTNR1H2NR1H3
SCHEMBL4895487 0.77 NR1H2 (0.34) MAPTNPC1RAB9AKDM4EALDH1A1
SCHEMBL12879690 0.74
Hydrochloric Acid SCHEMBL6907397 0.73 METAP1 (0.32) METAP1
SCHEMBL14407364 0.73 NR1H2 (0.35) ALDH1A1ACHENR1H2NR1H3HTR2C
SCHEMBL12879655 0.73 ESR1 (0.40) MAPTNPC1RAB9AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8084559-B2 Ethylene-vinylcyclohexane copolymers SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-27 US disclosed
US-20080161514-A1 Transition Metal Complex, Process For Producing Said Transition Metal Complex, Substituent-Carrying Fluorene Compound, Process For Producing Said Fluorene Compound, Catalyst Component For Olefin Polymerization, Catalyst For Olefin Polymerization, and Process For Producing Olefin Polymer SUMITOMO CHEMICAL COMPANY, LIMTIED (JP) 2008-07-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161514-A1 Transition Metal Complex, Process For Producing Said Transition Metal Complex, Substituent-Carrying Fluorene Compound, Process For Producing Said Fluorene Compound, Catalyst Component For Olefin Polymerization, Catalyst For Olefin Polymerization, and Process For Producing Olefin Polymer AOC2, ACSL1, ACSL3 MAPT 3437/4885NPC1 1751/4885RAB9A 1868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.