Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 13/20 | 0.57 |
| ▸ | SLC6A4 known ✓ | P31645 | 12/20 | 0.57 |
| ▸ | HTR2B known ✓ | P41595 | 6/20 | 0.57 |
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.57 |
| ▸ | HTR1A known ✓ | P08908 | 8/20 | 0.47 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.38 |
| ▸ | VPS4B | O75351 | 1/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL4900020 | 1.00 | DRD2 (0.57) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| SCHEMBL4904454 | 0.95 | SLC6A4 (0.60) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| SCHEMBL4899330 | 0.95 | SLC6A4 (0.60) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| SCHEMBL4897995 | 0.95 | SLC6A4 (0.60) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| SCHEMBL4902811 | 0.95 | SLC6A4 (0.60) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| Malic Acid SCHEMBL5531253 | 0.91 | DRD2 (0.55) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| SCHEMBL4903738 | 0.90 | SLC6A4 (0.53) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| SCHEMBL4904197 | 0.89 | SLC6A4 (0.60) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| SCHEMBL4905430 | 0.89 | SLC6A4 (0.61) | DRD2SLC6A4HTR2BHTR2AHTR1A | |
| SCHEMBL14196480 | 0.89 | SLC6A4 (0.61) | DRD2SLC6A4HTR2BHTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | disclosed |
| US-7297704-B2 | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | WYETH (US) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | TPH1, TPH2, HTR2C | DRD2 147/4885SLC6A4 25/4885HTR2B 16/4885 |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | TPH1, TPH2, HTR2C | DRD2 147/4885SLC6A4 25/4885HTR2B 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.