Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908025 | 0.93 | MMP9 (0.42) | KEAP1NFE2L2MMP9MMP2MAPT | |
| SCHEMBL4911874 | 0.91 | MAOA (0.43) | KEAP1NFE2L2MMP9MMP2MAPT | |
| SCHEMBL4897627 | 0.91 | KEAP1 (0.48) | KEAP1NFE2L2MMP9MMP2KMT2A | |
| SCHEMBL4894413 | 0.90 | MMP2 (0.49) | KEAP1NFE2L2MMP9MMP2MAPT | |
| SCHEMBL4904032 | 0.90 | KEAP1 (0.49) | KEAP1NFE2L2MMP9MMP2MAPT | |
| SCHEMBL4898047 | 0.89 | MAPT (0.47) | MMP9MMP2MAPTKMT2AALDH1A1 | |
| SCHEMBL4895785 | 0.86 | KEAP1 (0.49) | KEAP1NFE2L2MMP9MMP2MAPT | |
| SCHEMBL4895665 | 0.84 | LMNA (0.41) | KEAP1NFE2L2MAPTALDH1A1TSHR | |
| SCHEMBL4900687 | 0.83 | ESR1 (0.39) | KEAP1NFE2L2MMP9MAPTADAM17 | |
| SCHEMBL4906732 | 0.83 | LMNA (0.47) | KEAP1NFE2L2MMP9MMP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | KEAP1 714/4885NFE2L2 451/4885MMP9 4666/4885 |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | KEAP1 810/4885NFE2L2 446/4885MMP9 4632/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | KEAP1 810/4885NFE2L2 446/4885MMP9 4632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.