Sugi Predict

Sugi Predict / Compounds / SCHEMBL4904032

SCHEMBL4904032

SCHEMBL4904032

CCN(c1ccc(OCc2ccc(F)cc2)cc1)S(=O)(=O)c1ccc(C)c(C(=O)OC)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 4/20 0.49
▸ NFE2L2 Q16236 4/20 0.49
▸ MMP9 P14780 3/20 0.47
▸ MMP2 P08253 2/20 0.47
▸ MAPT P10636 2/20 0.46
▸ ADAM17 P78536 2/20 0.45
▸ MMP1 P03956 1/20 0.45
▸ MMP14 P50281 1/20 0.45
▸ LMNA P02545 2/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ KMT2A Q03164 2/20 0.43
▸ CA12 O43570 1/20 0.43
▸ CA1 P00915 1/20 0.43
▸ CA2 P00918 1/20 0.43
▸ CA7 P43166 1/20 0.43
▸ CA9 Q16790 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4906221 0.93 MMP9 (0.47) KEAP1NFE2L2MMP9MMP2MAPT
SCHEMBL4902970 0.92 KEAP1 (0.48) KEAP1NFE2L2MMP9MAPTADAM17
SCHEMBL4906453 0.91 LMNA (0.48) KEAP1NFE2L2MMP9MAPTADAM17
SCHEMBL4895775 0.91 ALDH1A1 (0.48) MMP9MMP2MAPTADAM17MMP1
SCHEMBL4895785 0.91 KEAP1 (0.49) KEAP1NFE2L2MMP9MMP2MAPT
SCHEMBL4905129 0.90 MMP13 (0.52) KEAP1NFE2L2MMP9MAPTADAM17
SCHEMBL4897482 0.90 LMNA (0.53) KEAP1NFE2L2MMP9MMP2MAPT
SCHEMBL4899758 0.90 MMP2 (0.49) KEAP1NFE2L2MMP9MMP2MAPT
SCHEMBL4904039 0.90 KEAP1 (0.47) KEAP1NFE2L2MMP9MMP2MAPT
SCHEMBL4903997 0.89 MAPT (0.49) MAPTLMNAALDH1A1SMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
EP-1765796-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Inc. (US) 2007-03-28 — — EP disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
WO-2006003495-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-01-12 — — WO disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD KEAP1 714/4885NFE2L2 451/4885MMP9 4666/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD KEAP1 810/4885NFE2L2 446/4885MMP9 4632/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD KEAP1 810/4885NFE2L2 446/4885MMP9 4632/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.