Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.58 |
| ▸ | HTR1A | P08908 | 9/20 | 0.58 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11160824 | 0.75 | DRD2 (0.56) | DRD2HTR1ADRD1HTR2ADRD3 | |
| SCHEMBL31029854 | 0.74 | DRD2 (1.00) | DRD2HTR1ADRD1HTR2AHTR7 | |
| SCHEMBL29723260 | 0.74 | DRD2 (1.00) | DRD2HTR1ADRD1HTR2AHTR7 | |
| SCHEMBL59765 | 0.74 | DRD2 (1.00) | DRD2HTR1ADRD1HTR2AHTR7 | |
| SCHEMBL31079473 | 0.74 | DRD2 (1.00) | DRD2HTR1ADRD1HTR2AHTR7 | |
| SCHEMBL25173335 | 0.74 | DRD2 (1.00) | DRD2HTR1ADRD1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL11162051 | 0.74 | DRD2 (0.55) | DRD2HTR1ADRD1HTR2ADRD3 | |
| Chloromethane SCHEMBL11396015 | 0.73 | DRD2 (0.54) | DRD2HTR1ADRD1HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL11707353 | 0.73 | DRD2 (0.97) | DRD2HTR1ADRD1HTR2AHTR7 | |
| Bromide SCHEMBL11710282 | 0.73 | DRD2 (0.97) | DRD2HTR1ADRD1HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096909-A1 | APOMORPHINE INHIBITORS OF AMYLOID-BETA (ABETA) FIBRIL FORMATION AND THEIR USE IN AMYLOIDOSIS BASED DISEASE | CYTOKINE PHARMASCIENCES, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20030187011-A1 | Apomorphine inhibitors of amyloid-beta (Abeta) fibril formation and their use in amyloidosis based disease | CYTOKINE PHARMASCIENCES, INC. | 2003-10-02 | — | — | US | disclosed |
| WO-2003053356-A2 | APOMORPHINE INHIBITORS OF AMYLOID-β (Aβ) FIBRIL FORMATION AND THEIR USE IN AMYLOIDOSIS BASED DISEASE | CYTOKINE PHARMASCIENCES, INC. (US) | 2003-07-03 | — | — | WO | disclosed |
| US-4120964-A | HYPOTENSIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1978-10-17 | — | — | US | disclosed |
| US-4120964-A | HYPOTENSIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1978-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096909-A1 | APOMORPHINE INHIBITORS OF AMYLOID-BETA (ABETA) FIBRIL FORMATION AND THEIR USE IN AMYLOIDOSIS BASED DISEASE | APP, PNMT, APOB | DRD2 168/4885HTR1A 44/4885DRD1 145/4885 |
| US-20030187011-A1 | Apomorphine inhibitors of amyloid-beta (Abeta) fibril formation and their use in amyloidosis based disease | PNMT, APP, MAPT | DRD2 269/4885HTR1A 41/4885DRD1 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.