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SCHEMBL4908462

SCHEMBL4908462

CCCCC1(O)C(=O)N(c2ccccc2)N(c2ccc(O)cc2)C1=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.59
▸ PKM P14618 1/20 0.59
▸ LMNA P02545 5/20 0.57
▸ ALDH1A1 P00352 4/20 0.57
▸ CYP3A4 P08684 2/20 0.57
▸ CYP2C19 P33261 2/20 0.57
▸ MAPK1 P28482 2/20 0.57
▸ CYP1A2 P05177 1/20 0.57
▸ CYP2C9 P11712 1/20 0.57
▸ TP53 P04637 1/20 0.57
▸ MAPT P10636 1/20 0.57
▸ HPGD P15428 1/20 0.57
▸ PTGS1 P23219 1/20 0.57
▸ RAB9A P51151 1/20 0.57
▸ NAPRT Q6XQN6 1/20 0.57
▸ ELANE P08246 2/20 0.48
▸ SMN1; SMN2 Q16637 3/20 0.46
▸ HTT P42858 2/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ KMT2A Q03164 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5956271 0.93 KDM4E (0.68) KDM4EPKMLMNAALDH1A1CYP3A4
SCHEMBL27764700 0.86 KDM4E (0.44) KDM4EPKMLMNAALDH1A1CYP3A4
SCHEMBL27786323 0.85 KDM4E (0.44) KDM4EPKMLMNAALDH1A1CYP3A4
SCHEMBL4915282 0.85 KDM4E (0.56) KDM4EPKMLMNAALDH1A1CYP3A4
SCHEMBL5083344 0.75 KDM4E (1.00) KDM4EPKMLMNAALDH1A1CYP3A4
SCHEMBL4731087 0.74 KDM4E (0.77) KDM4EPKMLMNAALDH1A1CYP3A4
SCHEMBL9751918 0.74 KDM4E (0.63) KDM4EPKMLMNAALDH1A1CYP3A4
SCHEMBL17205602 0.74 KDM4E (0.44) KDM4EPKMLMNAALDH1A1CYP2C19
SCHEMBL9457060 0.72 KDM4E (0.61) KDM4EPKMLMNAALDH1A1CYP3A4
Oxyphenbutazone Anhydrous SCHEMBL25857 0.72 LMNA (1.00) KDM4EPKMLMNAALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1194409-B1 PYRAZOLIDINOL COMPOUNDS VIRAL ASA A (NO) 2006-02-01 — — EP claimed
US-20040152751-A1 Pyrazolidinol compounds TJOTTA ENOK (NO) 2004-08-05 — — US claimed
EP-4139468-A1 ENANTIOSELECTIVE CHEMO-ENZYMATIC SYNTHESIS OF OPTICALLY ACTIVE AMINO AMIDE COMPOUNDS Pharmazell GmbH (DE) 2023-03-01 — — EP disclosed
US-7663000-B2 cytosine suppressive antiinflammatory agents; viricides; immunomodulators A-VIRAL ASA (NO) 2010-02-16 — — US disclosed
US-7663000-B2 cytosine suppressive antiinflammatory agents; viricides; immunomodulators A-VIRAL ASA (NO) 2010-02-16 — — US disclosed
US-20080287390-A1 Pyrazolidinol compounds A-VIRAL AS (NO) 2008-11-20 — — US disclosed
US-20080287390-A1 Pyrazolidinol compounds A-VIRAL AS (NO) 2008-11-20 — — US disclosed
US-20080287390-A1 Pyrazolidinol compounds A-VIRAL AS (NO) 2008-11-20 — — US disclosed
US-20080262068-A1 Method of Tonic Treatment With Oxyphenbutazone Derivatives A-VIRAL ASA (NO) 2008-10-23 — — US disclosed
US-20080262068-A1 Method of Tonic Treatment With Oxyphenbutazone Derivatives A-VIRAL ASA (NO) 2008-10-23 — — US disclosed
US-20070155812-A1 Thio-substituted phenbutazone compounds as anti-inflammatory, anti-viral and immunomodulatory agents DEKKERS DAVID W C 2007-07-05 — — US disclosed
US-20070112072-A1 Quinoneimines of malonic acid diamides A-VIRAL ASA (NO) 2007-05-17 — — US disclosed
US-20070037772-A1 Pyrazolidinol compounds A-VIRAL AS (NO) 2007-02-15 — — US disclosed
US-20070037772-A1 Pyrazolidinol compounds A-VIRAL AS (NO) 2007-02-15 — — US disclosed
US-20060121449-A1 Method for selection of compounds which inhibit clonal cell growth and use thereof TJOTTA ENOK 2006-06-08 — — US disclosed
EP-1194409-B1 PYRAZOLIDINOL COMPOUNDS VIRAL ASA A (NO) 2006-02-01 — — EP disclosed
EP-1549742-A1 METHOD FOR SELECTION OF COMPOUNDS WHICH INHIBIT CLONAL CELL GROWTH AND USE THEREOF Tjötta, Enok (NO) 2005-07-06 — — EP disclosed
US-6852749-B1 Pyrazolidinol compounds A-VIRAL AS (NO) 2005-02-08 — — US disclosed
US-20040152751-A1 Pyrazolidinol compounds TJOTTA ENOK (NO) 2004-08-05 — — US disclosed
WO-2004055175-A1 METHOD FOR SELECTION OF COMPOUNDS WHICH INHIBIT CLONAL CELL GROWTH AND USE THEREOF TJOETTA ENOK (NO) 2004-07-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080262068-A1 Method of Tonic Treatment With Oxyphenbutazone Derivatives HTT, NFATC1, BACH1 KDM4E 2131/4885PKM 1925/4885LMNA 3740/4885
US-20080287390-A1 Pyrazolidinol compounds NOX5, TPMT, ICOS KDM4E 449/4885PKM 586/4885LMNA 4868/4885
US-20070155812-A1 Thio-substituted phenbutazone compounds as anti-inflammatory, anti-viral and immunomodulatory agents MSR1, CD4, SSB KDM4E 2041/4885PKM 3580/4885LMNA 4693/4885
US-20070037772-A1 Pyrazolidinol compounds NOX5, TPMT, ICOS KDM4E 449/4885PKM 586/4885LMNA 4868/4885
US-20040152751-A1 Pyrazolidinol compounds NOX5, TPMT, ICOS KDM4E 449/4885PKM 586/4885LMNA 4868/4885
US-20060121449-A1 Method for selection of compounds which inhibit clonal cell growth and use thereof CD14, MKI67, CD69 KDM4E 4556/4885PKM 2620/4885LMNA 1490/4885
US-20070112072-A1 Quinoneimines of malonic acid diamides SQOR, MDH2, ME3 KDM4E 2704/4885PKM 2113/4885LMNA 4608/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.