Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099825 | 0.81 | ALDH1A1 (0.43) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL31030237 | 0.81 | ALDH1A1 (0.43) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL4455694 | 0.73 | ALDH1A1 (0.42) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL28981243 | 0.69 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL5179394 | 0.69 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL223759 | 0.68 | ALDH1A1 (0.45) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL10573026 | 0.67 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL9819791 | 0.67 | MEN1 (0.40) | ALDH1A1KMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL452908 | 0.67 | NPC1 (0.49) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL3506845 | 0.67 | NPC1 (0.49) | ALDH1A1HPGDMAPTGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080103163-A1 | Antipruritics | OYAMA TATSUYA | 2008-05-01 | — | — | US | disclosed |
| US-20080103162-A1 | Antipruritics | OYAMA TATSUYA | 2008-05-01 | — | — | US | disclosed |
| US-20060030565-A1 | Amide derivatives and nociceptin antagonists | JAPAN TOBACCO INC. | 2006-02-09 | — | — | US | disclosed |
| US-6903094-B2 | Amide derivatives and nociceptin antagonists | JAPAN TABACCO, INC. (JP) | 2005-06-07 | — | — | US | disclosed |
| US-20040116450-A1 | Antipruritics | NIPPON SHINYAKU CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1371376-A1 | ANTIPRURITICS | Nippon Shinyaku Co., Ltd. (JP) | 2003-12-17 | — | — | EP | disclosed |
| US-20030055087-A1 | Amide derivatives and nociceptin antagonists | JAPAN TOBACCO INC. | 2003-03-20 | — | — | US | disclosed |
| US-6410561-B1 | ANALGESICS | JAPAN TOBACCO INC. (JP) | 2002-06-25 | — | — | US | disclosed |
| EP-1072263-A1 | AMIDE DERIVATIVES AND NOCICEPTIN ANTAGONISTS | JAPAN TOBACCO INC. (JP) | 2001-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055087-A1 | Amide derivatives and nociceptin antagonists | OPRL1, OPRD1, OPRK1 | ALDH1A1 2407/4885HPGD 1358/4885MAPT 3992/4885 |
| US-20080103162-A1 | Antipruritics | ITCH, NTSR1, OPRL1 | ALDH1A1 3188/4885HPGD 3332/4885MAPT 353/4885 |
| US-20080103163-A1 | Antipruritics | ITCH, OPRL1, NTSR1 | ALDH1A1 2960/4885HPGD 3371/4885MAPT 312/4885 |
| US-20060030565-A1 | Amide derivatives and nociceptin antagonists | OPRL1, OPRD1, OPRM1 | ALDH1A1 2404/4885HPGD 1252/4885MAPT 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.