Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | MARS1 | P56192 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20636709 | 0.79 | KDM4E (0.50) | HSD17B10KMT2AMEN1LMNATSHR | |
| SCHEMBL17252253 | 0.79 | TP53 (0.44) | HSD17B10KMT2AMEN1LMNATSHR | |
| SCHEMBL18674224 | 0.79 | APOBEC3A (0.42) | KMT2AMEN1KMOTP53APOBEC3A | |
| SCHEMBL19957816 | 0.78 | PPARG (0.44) | HSD17B10KMT2AMEN1LMNATSHR | |
| SCHEMBL17252261 | 0.78 | MARS1 (0.41) | HSD17B10KMT2AMEN1LMNATSHR | |
| SCHEMBL4970217 | 0.78 | ATM (0.38) | HSD17B10KMT2AMEN1LMNATSHR | |
| SCHEMBL19957973 | 0.77 | TP53 (0.42) | HSD17B10KMT2AMEN1LMNATSHR | |
| SCHEMBL4914023 | 0.76 | NPC1 (0.44) | LMNATSHRTP53APOBEC3AAPOBEC3G | |
| SCHEMBL21488491 | 0.76 | KDM4E (0.44) | TSHRTP53APOBEC3AAPOBEC3GKDM4E | |
| SCHEMBL27471443 | 0.74 | NOTUM (0.48) | HSD17B10KMT2AMEN1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388585-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES INC (US) | 2025-12-25 | — | — | US | disclosed |
| EP-4638436-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2025-10-29 | — | — | EP | disclosed |
| US-12448388-B2 | PRMT5 inhibitors and uses thereof | GILEAD SCIENCES, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| US-20240376110-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. | 2024-11-14 | — | — | US | disclosed |
| WO-2024220917-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
| US-20240254118-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. | 2024-08-01 | — | — | US | disclosed |
| WO-2024137852-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024137852-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| US-20230348496-A1 | PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | SYNGENTA CROP PROTECTION AG (CH) | 2023-11-02 | — | — | US | disclosed |
| US-20230348496-A1 | PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | SYNGENTA CROP PROTECTION AG (CH) | 2023-11-02 | — | — | US | disclosed |
| EP-3139743-B1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AG (DE) | 2018-03-14 | — | — | EP | disclosed |
| EP-3139743-B1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AG (DE) | 2018-03-14 | — | — | EP | disclosed |
| US-20170088548-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-03-30 | — | — | US | disclosed |
| EP-3139743-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2017-03-15 | — | — | EP | disclosed |
| WO-2015169776-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AG (DE) | 2015-11-12 | — | — | WO | disclosed |
| WO-2015169776-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AG (DE) | 2015-11-12 | — | — | WO | disclosed |
| EP-1778685-B1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SANOL ARZNEI SCHWARZ GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| US-20080051409-A1 | Indolizine Carboxamides and Aza and Diaza Derivatives Thereof | SCHWARZ PHARMA AG (DE) | 2008-02-28 | — | — | US | disclosed |
| EP-1778685-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015737-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250388585-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT1, PRMT5, PRMT6 | HSD17B10 2485/4885KMT2A 67/4885MEN1 730/4885 |
| US-20240376110-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT9 | HSD17B10 2805/4885KMT2A 52/4885MEN1 406/4885 |
| US-20080051409-A1 | Indolizine Carboxamides and Aza and Diaza Derivatives Thereof | GRIN2A, GRIN2C, GRIN1 | HSD17B10 3610/4885KMT2A 455/4885MEN1 1227/4885 |
| US-12448388-B2 | PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT9 | HSD17B10 2805/4885KMT2A 52/4885MEN1 406/4885 |
| US-20170088548-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | NISCH, CATSPER1, KCNH1 | HSD17B10 4047/4885KMT2A 3288/4885MEN1 4661/4885 |
| US-20240254118-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT9 | HSD17B10 3023/4885KMT2A 59/4885MEN1 533/4885 |
| US-20230348496-A1 | PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | FOXM1, GLRX3, ACHE | HSD17B10 2565/4885KMT2A 1481/4885MEN1 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.