Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20418095 | 0.76 | HTR2A (0.46) | HSD17B10HTR2ATNKS2KDM4EALDH1A1 | |
| SCHEMBL28870083 | 0.75 | HSD17B10 (0.67) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL19573959 | 0.74 | TNKS2 (0.49) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL1567417 | 0.74 | HTR2A (0.40) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL31667419 | 0.74 | TNKS2 (0.49) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL19573960 | 0.74 | TNKS2 (0.49) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL1708832 | 0.74 | TNKS2 (0.49) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL17201050 | 0.74 | HTR2A (0.49) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL22397202 | 0.74 | HSD17B10 (0.51) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL19786249 | 0.74 | HTR2A (0.49) | HSD17B10HTR2AHTR2CHTR2BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110467558-B | Reaction method for synthesizing 3-aminoisoindolinone under catalysis of nickel | 山东省科学院新材料研究所 | 2022-09-16 | — | — | CN | claimed |
| CN-110467558-A | A kind of nickel catalyzes and synthesizes the reaction method of 3- amido isoindolinone | NEW MATERIAL RES INST SHANDONG ACADEMY SCIENCES | 2019-11-19 | — | — | CN | claimed |
| EP-1026207-B1 | Pigment particle growth and/or crystal phase directors | CIBA SC HOLDING AG (CH) | 2006-02-22 | — | — | EP | claimed |
| CN-115666575-A | Compound and use thereof | 福宏治疗公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-110467558-B | Reaction method for synthesizing 3-aminoisoindolinone under catalysis of nickel | 山东省科学院新材料研究所 | 2022-09-16 | — | — | CN | disclosed |
| CN-110467558-B | Reaction method for synthesizing 3-aminoisoindolinone under catalysis of nickel | 山东省科学院新材料研究所 | 2022-09-16 | — | — | CN | disclosed |
| CN-110467558-B | Reaction method for synthesizing 3-aminoisoindolinone under catalysis of nickel | 山东省科学院新材料研究所 | 2022-09-16 | — | — | CN | disclosed |
| CN-110467556-B | Nucleophilic reaction method for catalyzing imine ions and acetophenone by nickel | 山东省科学院新材料研究所 | 2022-09-02 | — | — | CN | disclosed |
| CN-114213425-A | Preparation process of carboxyl-X-rhodamine | 合肥华纳生物医药科技有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-110467558-A | A kind of nickel catalyzes and synthesizes the reaction method of 3- amido isoindolinone | NEW MATERIAL RES INST SHANDONG ACADEMY SCIENCES | 2019-11-19 | — | — | CN | disclosed |
| CN-110467558-A | A kind of nickel catalyzes and synthesizes the reaction method of 3- amido isoindolinone | NEW MATERIAL RES INST SHANDONG ACADEMY SCIENCES | 2019-11-19 | — | — | CN | disclosed |
| CN-110467558-A | A kind of nickel catalyzes and synthesizes the reaction method of 3- amido isoindolinone | NEW MATERIAL RES INST SHANDONG ACADEMY SCIENCES | 2019-11-19 | — | — | CN | disclosed |
| EP-1786773-B1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RES TECH LTD (GB) | 2017-03-01 | — | — | EP | disclosed |
| US-8258175-B2 | Prodrug; novel series of compounds which inhibit the MDM2-p53 interaction and have in vitro activity exerting an anti-tumour effect; cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-09-04 | — | — | US | disclosed |
| US-20080261917-A1 | Isoindolin-1-One Derivatives | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-10-23 | — | — | US | disclosed |
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |
| US-20050090559-A1 | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2005-04-28 | — | — | US | disclosed |
| EP-0029413-A1 | Iminoisoindolinone pigments, process for their preparation and their use | CIBA-GEIGY AG (CH) | 1981-05-27 | — | — | EP | disclosed |
| US-4231931-A | YELLOW TO RED HUES | CIBA-GEIGY CORPORATION (US) | 1980-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090559-A1 | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents | IL1B, NFKBIA, BBOX1 | HSD17B10 957/4885HTR2A 1470/4885HTR2C 289/4885 |
| US-20080261917-A1 | Isoindolin-1-One Derivatives | HCN3, NHERF1, SIGMAR1 | HSD17B10 1874/4885HTR2A 1519/4885HTR2C 1000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.