SCHEMBL491507

SCHEMBL491507

OB(O)c1cc(F)cc(C(F)(F)F)c1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 2/20 0.53
TRPV6 Q9H1D0 2/20 0.40
ORAI1 Q96D31 1/20 0.40
ORAI2 Q96SN7 1/20 0.40
ORAI3 Q9BRQ5 1/20 0.40
RXRA P19793 1/20 0.37
RXRB P28702 1/20 0.37
RXRG P48443 1/20 0.37
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
CES2 O00748 1/20 0.35
VNN1 O95497 3/20 0.33
XPO1 O14980 1/20 0.33
ITGB3 P05106 1/20 0.32
ITGAV P06756 1/20 0.32
MTOR P42345 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL126169 0.86 MGLL (0.61) MGLLTRPV6ORAI1ORAI2ORAI3
SCHEMBL16164272 0.86 MGLL (0.61) MGLLTRPV6ORAI1ORAI2ORAI3
SCHEMBL30036309 0.84 MGLL (0.59) MGLLTRPV6ORAI1ORAI2ORAI3
SCHEMBL28896242 0.84 MGLL (0.59) MGLLTRPV6ORAI1ORAI2ORAI3
SCHEMBL19552665 0.79 MGLL (0.37) MGLL
SCHEMBL2067336 0.78 MGLL (0.53) MGLLTRPV6ORAI1ORAI2ORAI3
SCHEMBL124847 0.78 CA1 (0.45) MGLLTRPV6ORAI1ORAI2ORAI3
SCHEMBL23527775 0.77 MGLL (0.52) MGLLTRPV6ORAI1ORAI2ORAI3
SCHEMBL1199146 0.77 MGLL (0.52) MGLLTRPV6ORAI1ORAI2ORAI3
SCHEMBL29956020 0.77 MGLL (0.52) MGLLTRPV6ORAI1ORAI2ORAI3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120033221-A Silicon-based composite material, preparation method thereof and secondary battery 兰溪致德新能源材料有限公司 2025-05-23 CN claimed
EP-3856179-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-05-13 EP disclosed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 EP disclosed
US-12552824-B2 C-mannoside compounds useful for the treatment of urinary tract infections GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2026-02-17 US disclosed
US-20250333383-A1 N-OXIDE COMPOUNDS AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2025-10-30 US disclosed
EP-4116302-B1 COMPOUND AND PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN PREPARATION OF THERAPEUTIC ANTI-CANCER DRUG TIANJIN JIKUN MEDICAL TECH CO LTD (CN) 2025-10-29 EP disclosed
WO-2025215450-A1 THIAZOLE COMPOUNDS AS SODIUM CHANNEL BLOCKERS SK BIOPHARMACEUTICALS CO., LTD. (KR) 2025-10-16 WO disclosed
US-20250179017-A1 CARBOXAMIDE COMPOUNDS AS PGE2 RECEPTOR ANTAGONISTS GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) 2025-06-05 US disclosed
US-12319683-B2 Azabenzimidazole compounds and pharmaceutical NIPPON SHINYAKU CO., LTD. (JP) 2025-06-03 US disclosed
EP-0808312-A1 INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST SMITHKLINE BEECHAM PLC (GB) 1997-11-26 EP disclosed
US-5616718-A USEFUL FOR MAKING 2,4-DIAMINOQUINAZOLINES; INSECTICIDES FMC CORPORATION (US) 1997-04-01 US disclosed
US-5593998-A 2,4-diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides FMC CORPORATION (US) 1997-01-14 US disclosed
US-5547954-A MIXED WITH AGRICULTURAL ACCEPTABLE CARRIER FMC CORPORATION (US) 1996-08-20 US disclosed
WO-1996023783-A1 INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST SMITHKLINE BEECHAM PLC (GB) 1996-08-08 WO disclosed
US-5534518-A Insecticidal substituted-2,4-diaminoquinazolines FMC CORPORATION (US) 1996-07-09 US disclosed
US-5532370-A FOR INSECTS INCLUDING LARVAE SUCH AS TOBACCO BUDWORM FMC CORPORATION (US) 1996-07-02 US disclosed
EP-0684824-A4 INSECTICIDAL SUBSTITUTED-2,4-DIAMINOQUINAZOLINES. FMC CORP (US) 1996-02-14 EP disclosed
EP-0684824-A1 INSECTICIDAL SUBSTITUTED-2,4-DIAMINOQUINAZOLINES FMC CORPORATION (US) 1995-12-06 EP disclosed
WO-1994018980-A1 INSECTICIDAL SUBSTITUTED-2,4-DIAMINOQUINAZOLINES FMC CORPORATION (US) 1994-09-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179017-A1 CARBOXAMIDE COMPOUNDS AS PGE2 RECEPTOR ANTAGONISTS PTGER1, PTGER2, CNR2 MGLL 557/4885TRPV6 130/4885ORAI1 677/4885
US-20250333383-A1 N-OXIDE COMPOUNDS AND USE THEREOF SCNN1B, SCN1B, SCN2B MGLL 2834/4885TRPV6 171/4885ORAI1 166/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH MGLL 1/4885TRPV6 2039/4885ORAI1 3640/4885
US-12552824-B2 C-mannoside compounds useful for the treatment of urinary tract infections MUC1, CD209, MAN2B2 MGLL 2371/4885TRPV6 1923/4885ORAI1 2149/4885
US-12319683-B2 Azabenzimidazole compounds and pharmaceutical PAM, CHRM3, AZI2 MGLL 3552/4885TRPV6 55/4885ORAI1 710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.