Ataciguat

Ataciguat

SCHEMBL491675

O=C(Nc1ccc(S(=O)(=O)N2CCOCC2)cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Cl)s1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GUCY1A1GUCY1A2GUCY1B1GUCY1B2

The experimentally established mechanism targets of Ataciguat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 13/20 0.64
MEN1 O00255 12/20 0.64
MAPT P10636 7/20 0.64
HTT P42858 5/20 0.64
LMNA P02545 5/20 0.64
SMN1; SMN2 Q16637 4/20 0.64
ALDH1A1 P00352 2/20 0.64
TDP1 Q9NUW8 1/20 0.58
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.52
MAPK1 P28482 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
RECQL P46063 1/20 0.51
F10 P00742 1/20 0.49
TP53 P04637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ataciguat SCHEMBL29370450 1.00 KMT2A (0.64) KMT2AMEN1MAPTHTTLMNA
Ataciguat SCHEMBL492158 0.99 KMT2A (0.63) KMT2AMEN1MAPTHTTLMNA
SCHEMBL13297364 0.91 KMT2A (0.62) KMT2AMEN1MAPTHTTLMNA
SCHEMBL10252896 0.91 ALDH1A1 (0.58) KMT2AMEN1MAPTHTTLMNA
SCHEMBL29424222 0.89 KMT2A (0.76) KMT2AMEN1MAPTHTTLMNA
SCHEMBL492486 0.89 KMT2A (0.59) KMT2AMEN1MAPTHTTLMNA
SCHEMBL491931 0.88 KMT2A (0.72) KMT2AMEN1MAPTHTTLMNA
SCHEMBL491936 0.87 KMT2A (0.61) KMT2AMEN1MAPTHTTLMNA
SCHEMBL491874 0.87 KMT2A (0.63) KMT2AMEN1MAPTHTTLMNA
SCHEMBL492533 0.86 KMT2A (0.60) KMT2AMEN1MAPTHTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220211702-A1 METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2022-07-07 US claimed
EP-3952992-A1 METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION Mayo Foundation for Medical Education and Research (US) 2022-02-16 EP claimed
WO-2020210707-A1 METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2020-10-15 WO claimed
US-9789126-B2 Methods and materials for treating calcific aortic valve stenosis MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2017-10-17 US claimed
EP-2207541-B1 USE OF SULFONYL-SUBSTITUTED 2-SULFONYLAMINOBENZOIC ACID N-PHENYLAMIDES IN THE TREATMENT OF PAIN SANOFI AVENTIS DEUTSCHLAND (DE) 2014-10-29 EP claimed
US-8518998-B2 Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2013-08-27 US claimed
US-20120108573-A1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM SANOFI-AVENTIS DEUTSCHLAND GMBH 2012-05-03 US claimed
US-8106213-B2 For example, 2-(4-chloro-phenylsulfonylamino)-4,5-dimethoxy-N-(4-(thiomorpholine-4-sulfonyl)-phenyl)-benzamide; for therapy and prophylaxis of cardiovascular diseases such as hypertension, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-01-31 US claimed
US-20110021505-A1 Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2011-01-27 US claimed
EP-2207541-A1 USE OF SULFONYL-SUBSTITUTED 2-SULFONYLAMINOBENZOIC ACID N-PHENYLAMIDES IN THE TREATMENT OF PAIN Sanofi-Aventis Deutschland GmbH (DE) 2010-07-21 EP claimed
WO-2009043495-A1 USE OF SULFONYL-SUBSTITUTED 2-SULFONYLAMINOBENZOIC ACID N-PHENYLAMIDES IN THE TREATMENT OF PAIN SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-04-09 WO claimed
US-20080096936-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them TELEVOX SOFTWARE, INCORPORATED 2008-04-24 US claimed
EP-1095016-B1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM SANOFI AVENTIS DEUTSCHLAND (DE) 2005-11-09 EP claimed
WO-2005042022-A2 COMBINATION OF AN ACTIVATOR OF SOLUBLEGUANYLATE CYCLASE AND AN ANGIOTENSIN II RECEPTOR ANTAGONIST PFIZER LIMITED (GB) 2005-05-12 WO claimed
US-20050059660-A1 activators of soluble guanylate cyclase, and inhibitors of angiotensin converting enzyme such as benazepril; treatment of cardiovascular or metabolic disorders PHARMACIA & UPJOHN COMPANY 2005-03-17 US claimed
WO-2005011727-A1 COMBINATION OF AN ACTIVATOR OF SOLUBLE GUANYLATE CYCLASE AND AN ACE-INHIBITOR FOR THE TREATMENT OF A CARDIOVASCULAR OR METABOLIC DISORDER PFIZER LIMITED (GB) 2005-02-10 WO claimed
US-20040186145-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH. 2004-09-23 US claimed
US-20020061887-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH 2002-05-23 US claimed
US-6335334-B1 HYPERTENSIVE AGENTS, ANTICOAGULANTS; CARDIOVASCULAR AND SEXUAL DISORDERS, ANGINA PECTORIS, AND ATHEROSCLEROSIS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-01-01 US claimed
US-12465605-B2 Methods and materials for gender-dependent treatment of cardiovascular dysfunction MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2025-11-11 US disclosed
EP-3538096-B1 TREATMENT OF CNS DISEASES WITH SGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2024-02-28 EP disclosed
US-20230381153-A1 TREATMENT OF CNS DISEASES WITH sGC STIMULATORS TISENTO THERAPEUTICS INC. 2023-11-30 US disclosed
EP-3998260-B1 SGC STIMULATORS CYCLERION THERAPEUTICS INC (US) 2023-11-01 EP disclosed
US-11731977-B2 SGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2023-08-22 US disclosed
EP-3872080-B1 FUSED BICYCLIC SGC STIMULATORS CYCLERION THERAPEUTICS INC (US) 2023-08-16 EP disclosed
US-11690828-B2 Treatment of CNS diseases with sGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2023-07-04 US disclosed
WO-2023018795-A1 NEP INHIBITORS FOR THE TREATMENT OF LAMINITIS CURTAILS LLC (US) 2023-02-16 WO disclosed
US-11572358-B2 Solid forms of an sGC stimulator CYCLERION THERAPEUTICS, INC. (US) 2023-02-07 US disclosed
US-20220211702-A1 METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2022-07-07 US disclosed
US-11357777-B2 Use of sGC stimulators for the treatment of nonalcoholic steatohepatitis (NASH) CYCLERION THERAPEUTICS, INC. (US) 2022-06-14 US disclosed
EP-3411026-B1 USE OF STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS (NASH) CYCLERION THERAPEUTICS INC (US) 2022-03-09 EP disclosed
US-20220062307-A1 METHODS AND MATERIALS FOR TREATING CALCIFIC AORTIC VALVE STENOSIS MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2022-03-03 US disclosed
EP-3952992-A1 METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION Mayo Foundation for Medical Education and Research (US) 2022-02-16 EP disclosed
US-20220023246-A1 STIMULATORS AND/OR ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE (SGC) IN COMBINATION WITH AN INHIBITOR OF NEUTRAL ENDOPEPTIDASE (NEP INHIBITOR) AND/OR AN ANGIOTENSIN AII ANTAGONIST AND THE USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2022-01-27 US disclosed
US-20220017515-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC. 2022-01-20 US disclosed
US-20220009937-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC. 2022-01-13 US disclosed
US-11207323-B2 sGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2021-12-28 US disclosed
US-11180493-B2 SGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2021-11-23 US disclosed
US-11166932-B2 Stimulators and/or activators of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and/or an angiotensin AII antagonist and the use thereof BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2021-11-09 US disclosed
US-20210214364-A1 sGC STIMULATORS CYCLERION THERAPEUTICS INC (US) 2021-07-15 US disclosed
US-20210188830-A1 SOLID FORMS OF AN SGC STIMULATOR CYCLERION THERAPEUTICS, INC. 2021-06-24 US disclosed
US-20210161893-A1 USE OF sGC STIMULATORS FOR THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS (NASH) CYCLERION THERAPEUTICS, INC. 2021-06-03 US disclosed
EP-3507291-B1 FUSED BICYCLIC SGC STIMULATORS CYCLERION THERAPEUTICS INC (US) 2021-05-26 EP disclosed
US-20210087198-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC. 2021-03-25 US disclosed
US-10927136-B2 Phosphorus prodrugs of pyrazolo-substituted pyrimidine sGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2021-02-23 US disclosed
US-10889577-B2 Solid forms of an sGC stimulator CYCLERION THERAPEUTICS, INC. (US) 2021-01-12 US disclosed
US-10858363-B2 SGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2020-12-08 US disclosed
US-10844064-B2 sGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2020-11-24 US disclosed
WO-2020210707-A1 METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2020-10-15 WO disclosed
US-20200316065-A1 sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2020-10-08 US disclosed
EP-3325013-B1 STIMULATORS / ACTIVATORS OF SOLUBLE GUANYLAT CYCLASE IN COMBINATION WITH A NEP-INHIBITOR AND/OR AN ANGIOTENSIN AII-ANTAGONIST AND THE USE THEREOF Bayer Pharma AG (DE) 2020-09-23 EP disclosed
US-10639308-B2 sGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2020-05-05 US disclosed
US-20200071318-A1 SGC STIMULATORS TISENTO THERAPEUTICS INC. 2020-03-05 US disclosed
US-20190345130-A1 SGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2019-11-14 US disclosed
US-20190343813-A1 TREATMENT OF CNS DISEASES WITH sGC STIMULATORS CYCLERION THERAPEUTICS, INC. (US) 2019-11-14 US disclosed
US-10472363-B2 SGC stimulators CYCLERION THERAPEUTICS, INC. (US) 2019-11-12 US disclosed
US-20190300555-A1 PHOSPHORUS PRODRUGS OF SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. 2019-10-03 US disclosed
US-20190284168-A1 PYRAZOLE DERIVATIES AS SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC 2019-09-19 US disclosed
US-20190248794-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC. 2019-08-15 US disclosed
EP-3291811-B1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) Bayer Pharma AG (DE) 2019-08-07 EP disclosed
US-20190167679-A1 sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2019-06-06 US disclosed
US-20190169179-A1 SOLID FORMS OF AN SGC STIMULATOR IRONWOOD PHARMACEUTICALS, INC. 2019-06-06 US disclosed
US-20190125709-A1 STIMULATORS AND/OR ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE (SGC) IN COMBINATION WITH AN INHIBITOR OF NEUTRAL ENDOPEPTIDASE (NEP INHIBITOR) AND/OR AN ANGIOTENSIN AII ANTAGONIST AND THE USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-05-02 US disclosed
US-10265314-B2 SGC stimulators in combination with additional treatment for the therapy of cystic fibrosis BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-04-23 US disclosed
US-20190031641-A1 PYRAZOLE DERIVATIVES AS SGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2019-01-31 US disclosed
US-10189809-B2 SGC stimulators IRONWOOD PHARMACEUTICALS, INC. (US) 2019-01-29 US disclosed
US-10189856-B2 Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) ADVERIO PHARMA GMBH (DE) 2019-01-29 US disclosed
US-10183021-B2 sGC stimulators IRONWOOD PHARMACEUTICALS, INC. (US) 2019-01-22 US disclosed
WO-2018153899-A1 SELECTIVE PARTIAL ADENOSINE A1 RECEPTOR AGONISTS IN COMBINATION WITH SOLUBLE GUANYLYL CYCLASE (SGC) STIMULATORS AND/OR ACTIVATORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-08-30 WO disclosed
EP-3092231-B1 SGC STIMULATORS IRONWOOD PHARMACEUTICALS INC (US) 2018-06-27 EP disclosed
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-06-21 US disclosed
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-06-21 US disclosed
WO-2018111795-A2 USE OF SGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2018-06-21 WO disclosed
US-20180155345-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2018-06-07 US disclosed
WO-2018089330-A2 SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed
WO-2018089328-A1 TREATMENT OF CNS DISEASES WITH SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed
WO-2018045276-A1 FUSED BICYCLIC SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2018-03-08 WO disclosed
US-20180065971-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC. 2018-03-08 US disclosed
US-20170305878-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2017-10-26 US disclosed
US-20170298055-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2017-10-19 US disclosed
US-20170291889-A1 PYRAZOLE DERIVATIVES AS SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2017-10-12 US disclosed
US-20170291902-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2017-10-12 US disclosed
WO-2017136309-A1 USE OF sGC STIMULATORS FOR THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS (NASH) IRONWOOD PHARMACEUTICALS, INC. (US) 2017-08-10 WO disclosed
US-20170136019-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2017-05-18 US disclosed
US-20170112845-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2017-04-27 US disclosed
US-20170065586-A1 SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2017-03-09 US disclosed
US-9586937-B2 sGC stimulators IRONWOOD PHARMACEUTICALS, INC. (US) 2017-03-07 US disclosed
WO-2017013010-A1 STIMULATORS AND/OR ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE (SGC) IN COMBINATION WITH AN INHIBITOR OF NEUTRAL ENDOPEPTIDASE (NEP INHIBITOR) AND/OR AN ANGIOTENSIN AII ANTAGONIST AND THE USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-01-26 WO disclosed
US-20160347738-A1 sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2016-12-01 US disclosed
US-20160324856-A1 USE OF SGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS CYCLERION THERAPEUTICS, INC. 2016-11-10 US disclosed
US-9487508-B2 SGC stimulators IRONWOOD PHARMACEUTICALS, INC. (US) 2016-11-08 US disclosed
US-9481689-B2 sGC stimulators IRONWOOD PHARMACEUTICALS, INC. (US) 2016-11-01 US disclosed
US-20160311826-A1 SGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2016-10-27 US disclosed
US-20160175307-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2016-06-23 US disclosed
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELl SCHAFT (DE) 2016-06-09 US disclosed
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELl SCHAFT (DE) 2016-06-09 US disclosed
US-20160031903-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2016-02-04 US disclosed
US-20150342954-A1 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2015-12-03 US disclosed
US-9139564-B2 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators IRONWOOD PHARMACEUTICALS, INC. (US) 2015-09-22 US disclosed
US-20150250795-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2015-09-10 US disclosed
US-20150232461-A1 SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2015-08-20 US disclosed
US-9024069-B2 NONOate derivatives and uses thereof IRONWOOD PHARMACEUTICALS, INC. (US) 2015-05-05 US disclosed
US-20140323448-A1 sGC STIMULATORS Ironwood Pharmaceuticals Inc. (US) 2014-10-30 US disclosed
EP-2207541-B1 USE OF SULFONYL-SUBSTITUTED 2-SULFONYLAMINOBENZOIC ACID N-PHENYLAMIDES IN THE TREATMENT OF PAIN SANOFI AVENTIS DEUTSCHLAND (DE) 2014-10-29 EP disclosed
US-20140288079-A1 SGC STIMULATORS OF SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-09-25 US disclosed
US-20140288079-A1 SGC STIMULATORS OF SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-09-25 US disclosed
US-8748442-B2 sGC stimulators IRONWOOD PHARMACEUTICALS, INC. (US) 2014-06-10 US disclosed
US-20140135295-A1 NONOATE DERIVATIVES AND USES THEREOF IRONWOOD PHARMACEUTICALS (US) 2014-05-15 US disclosed
US-20140038956-A1 Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-02-06 US disclosed
US-20140038956-A1 Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-02-06 US disclosed
US-8541410-B2 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2013-09-24 US disclosed
US-8518998-B2 Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2013-08-27 US disclosed
US-20130178475-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2013-07-11 US disclosed
US-20130158028-A1 USE OF STIMULATORS AND ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING SICKLE-CELL ANEMIA AND CONSERVING BLOOD SUBSTITUTES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-06-20 US disclosed
US-20130158028-A1 USE OF STIMULATORS AND ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING SICKLE-CELL ANEMIA AND CONSERVING BLOOD SUBSTITUTES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-06-20 US disclosed
US-20130158028-A1 USE OF STIMULATORS AND ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING SICKLE-CELL ANEMIA AND CONSERVING BLOOD SUBSTITUTES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-06-20 US disclosed
US-8461348-B2 Heterocyclic derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-06-11 US disclosed
US-8461348-B2 Heterocyclic derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-06-11 US disclosed
US-20130123354-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2013-05-16 US disclosed
US-20130035340-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-02-07 US disclosed
US-20120108573-A1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM SANOFI-AVENTIS DEUTSCHLAND GMBH 2012-05-03 US disclosed
US-8106213-B2 For example, 2-(4-chloro-phenylsulfonylamino)-4,5-dimethoxy-N-(4-(thiomorpholine-4-sulfonyl)-phenyl)-benzamide; for therapy and prophylaxis of cardiovascular diseases such as hypertension, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-01-31 US disclosed
US-20120022028-A1 SGC STIMULATORS OR SGC ACTIVATORS IN COMBINATION WITH PDE5 INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-01-26 US disclosed
US-20110159474-A1 SOLUTIONS FOR PERFUSING AND PRESERVING ORGANS AND TISSUES BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-06-30 US disclosed
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-02-03 US disclosed
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-02-03 US disclosed
US-20110021505-A1 Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2011-01-27 US disclosed
WO-2010081647-A2 SGC STIMULATORS OF SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-07-22 WO disclosed
EP-2207541-A1 USE OF SULFONYL-SUBSTITUTED 2-SULFONYLAMINOBENZOIC ACID N-PHENYLAMIDES IN THE TREATMENT OF PAIN Sanofi-Aventis Deutschland GmbH (DE) 2010-07-21 EP disclosed
US-20100016305-A1 novel use of activators and stimulators of soluble guanylate cyclase for the prevention or treatment of renal disorders BAYER HEALTHCARE AG (DE) 2010-01-21 US disclosed
US-20090221573-A1 Use of Activators of Soluble Guanylate Cyclase for Promoting Wound Healing BAYER HEALTHCARE AG (DE) 2009-09-03 US disclosed
WO-2009043495-A1 USE OF SULFONYL-SUBSTITUTED 2-SULFONYLAMINOBENZOIC ACID N-PHENYLAMIDES IN THE TREATMENT OF PAIN SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-04-09 WO disclosed
US-20080096936-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them TELEVOX SOFTWARE, INCORPORATED 2008-04-24 US disclosed
US-7326789-B2 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-02-05 US disclosed
WO-2007009607-A1 NOVEL USE OF ACTIVATORS AND STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR THE PREVENTION OR TREATMENT OF RENAL DISORDERS BAYER HEALTHCARE AG (DE) 2007-01-25 WO disclosed
EP-1614678-A2 Sulfur substituted sulfonylaminocarboxylic acid N-heteroarylamides, their preparation, their use and pharmaceutical preparations comprising them Sanofi-Aventis Deutschland GmbH (DE) 2006-01-11 EP disclosed
EP-1095016-B1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM SANOFI AVENTIS DEUTSCHLAND (DE) 2005-11-09 EP disclosed
WO-2005042022-A2 COMBINATION OF AN ACTIVATOR OF SOLUBLEGUANYLATE CYCLASE AND AN ANGIOTENSIN II RECEPTOR ANTAGONIST PFIZER LIMITED (GB) 2005-05-12 WO disclosed
US-6881735-B2 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-04-19 US disclosed
US-20050059660-A1 activators of soluble guanylate cyclase, and inhibitors of angiotensin converting enzyme such as benazepril; treatment of cardiovascular or metabolic disorders PHARMACIA & UPJOHN COMPANY 2005-03-17 US disclosed
WO-2005011727-A1 COMBINATION OF AN ACTIVATOR OF SOLUBLE GUANYLATE CYCLASE AND AN ACE-INHIBITOR FOR THE TREATMENT OF A CARDIOVASCULAR OR METABOLIC DISORDER PFIZER LIMITED (GB) 2005-02-10 WO disclosed
US-20040186145-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH. 2004-09-23 US disclosed
US-20020061887-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH 2002-05-23 US disclosed
US-6335334-B1 HYPERTENSIVE AGENTS, ANTICOAGULANTS; CARDIOVASCULAR AND SEXUAL DISORDERS, ANGINA PECTORIS, AND ATHEROSCLEROSIS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-01-01 US disclosed
EP-1095016-A1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM Aventis Pharma Deutschland GmbH (DE) 2001-05-02 EP disclosed
WO-2000002851-A1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-01-20 WO disclosed
WO-2000002851-A1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-01-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (50 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200071318-A1 SGC STIMULATORS GUCY1A2, GMPS, PDE2A KMT2A 4675/4885MEN1 4141/4885MAPT 4780/4885
US-20130035340-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS PDE5A, PDE3B, PDE3A KMT2A 4107/4885MEN1 4037/4885MAPT 4882/4885
US-20140038956-A1 Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). PDE5A, PDE3A, PDE2A KMT2A 4077/4885MEN1 4083/4885MAPT 4843/4885
US-20140323448-A1 sGC STIMULATORS GUCY1A1, PTGIS, GUCY1B1 KMT2A 4149/4885MEN1 3461/4885MAPT 4837/4885
US-20120108573-A1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM GUCY1A1, GUCY1B1, GUCY1A2 KMT2A 4155/4885MEN1 2028/4885MAPT 4863/4885
US-20160324856-A1 USE OF SGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS SMN1; SMN2, PRKG1, GUCY1A2 KMT2A 4060/4885MEN1 2619/4885MAPT 4292/4885
US-10889577-B2 Solid forms of an sGC stimulator GUCY1A2, PRKG1, GUCY1A1 KMT2A 4389/4885MEN1 2771/4885MAPT 4405/4885
US-20110021505-A1 Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain SCN1A, SCN2A, CACNA1A KMT2A 568/4885MEN1 3830/4885MAPT 4467/4885
US-20190343813-A1 TREATMENT OF CNS DISEASES WITH sGC STIMULATORS GUCY1A2, GUCY1B2, PDE2A KMT2A 3687/4885MEN1 1983/4885MAPT 3160/4885
US-20220017515-A1 sGC STIMULATORS GUCY1A2, PRKG1, PDE2A KMT2A 4673/4885MEN1 4168/4885MAPT 4786/4885
US-20150250795-A1 sGC STIMULATORS PTGIS, GUCY1B1, GUCY1A1 KMT2A 4155/4885MEN1 3580/4885MAPT 4845/4885
US-20100016305-A1 novel use of activators and stimulators of soluble guanylate cyclase for the prevention or treatment of renal disorders GUCY1A2, GUCY1A1, GUCY1B2 KMT2A 4447/4885MEN1 2374/4885MAPT 4836/4885
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) PDE5A, PDE2A, PDE3A KMT2A 3871/4885MEN1 4593/4885MAPT 4858/4885
US-10472363-B2 SGC stimulators GUCY1A2, PRKG1, GMPS KMT2A 4533/4885MEN1 4282/4885MAPT 4733/4885
US-20210087198-A1 sGC STIMULATORS GUCY1A2, PRKG1, GMPS KMT2A 4533/4885MEN1 4282/4885MAPT 4733/4885
US-10858363-B2 SGC stimulators GUCY1A2, PRKG1, GMPS KMT2A 4533/4885MEN1 4282/4885MAPT 4733/4885
US-20170291889-A1 PYRAZOLE DERIVATIVES AS SGC STIMULATORS PTGIS, GMPS, NOS3 KMT2A 3988/4885MEN1 3903/4885MAPT 4697/4885
US-20190284168-A1 PYRAZOLE DERIVATIES AS SGC STIMULATORS PTGIS, GMPS, NOS3 KMT2A 3612/4885MEN1 3871/4885MAPT 4703/4885
US-20170305878-A1 sGC STIMULATORS GUCY1A1, PTGIS, GUCY1B1 KMT2A 4149/4885MEN1 3461/4885MAPT 4837/4885
US-20130158028-A1 USE OF STIMULATORS AND ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING SICKLE-CELL ANEMIA AND CONSERVING BLOOD SUBSTITUTES PDE5A, GUCY1A1, PDE2A KMT2A 3246/4885MEN1 2710/4885MAPT 4850/4885
US-20140135295-A1 NONOATE DERIVATIVES AND USES THEREOF SLC10A1, NOTUM, FASTKD5 KMT2A 3608/4885MEN1 1038/4885MAPT 2970/4885
US-20130178475-A1 sGC STIMULATORS GUCY1A1, PTGIS, GUCY1B1 KMT2A 4149/4885MEN1 3461/4885MAPT 4837/4885
US-11690828-B2 Treatment of CNS diseases with sGC stimulators GUCY1A2, GUCY1B2, PDE2A KMT2A 3687/4885MEN1 1983/4885MAPT 3160/4885
US-11207323-B2 sGC stimulators PTGIS, CGAS, GUCY1A1 KMT2A 4250/4885MEN1 2447/4885MAPT 4849/4885
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS PDE5A, PDE3A, GMPS KMT2A 4504/4885MEN1 4334/4885MAPT 4883/4885
US-20170291902-A1 sGC STIMULATORS GUCY1B1, GUCY1A1, PRKG1 KMT2A 2303/4885MEN1 3230/4885MAPT 4871/4885
US-20190169179-A1 SOLID FORMS OF AN SGC STIMULATOR GUCY1A2, PRKG1, GUCY1A1 KMT2A 4394/4885MEN1 2747/4885MAPT 4411/4885
US-20170298055-A1 sGC STIMULATORS GUCY1B1, GUCY1A1, PRKG2 KMT2A 3187/4885MEN1 3266/4885MAPT 4869/4885
US-20160175307-A1 sGC STIMULATORS GUCY1A1, PTGIS, GUCY1B1 KMT2A 4149/4885MEN1 3461/4885MAPT 4837/4885
US-10639308-B2 sGC stimulators PTGIS, CGAS, GUCY1A1 KMT2A 4250/4885MEN1 2447/4885MAPT 4849/4885
US-10265314-B2 SGC stimulators in combination with additional treatment for the therapy of cystic fibrosis PDE5A, GMPS, PDE3A KMT2A 4569/4885MEN1 4595/4885MAPT 4882/4885
US-20160347738-A1 sGC STIMULATORS PTGIS, CGAS, GUCY1A1 KMT2A 4250/4885MEN1 2447/4885MAPT 4849/4885
US-20150232461-A1 SGC STIMULATORS GUCY1B1, GUCY1A1, PRKG1 KMT2A 3461/4885MEN1 4477/4885MAPT 4855/4885
US-20180065971-A1 sGC STIMULATORS GUCY1A2, PRKG1, GMPS KMT2A 4533/4885MEN1 4282/4885MAPT 4733/4885
US-20110159474-A1 SOLUTIONS FOR PERFUSING AND PRESERVING ORGANS AND TISSUES GUCY1A1, GUCY1A2, PDE3B KMT2A 4626/4885MEN1 1506/4885MAPT 4645/4885
US-20190300555-A1 PHOSPHORUS PRODRUGS OF SGC STIMULATORS PRKG1, PRKG2, P2RY1 KMT2A 3243/4885MEN1 1824/4885MAPT 4856/4885
US-20160311826-A1 SGC STIMULATORS GUCY1A1, GUCY1B1, GUCY1A2 KMT2A 3344/4885MEN1 3637/4885MAPT 4863/4885
US-20150342954-A1 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS PTGIS, PDE3B, GMPS KMT2A 3914/4885MEN1 3284/4885MAPT 4801/4885
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF PDE3B, PDE5A, PDE2A KMT2A 3197/4885MEN1 2661/4885MAPT 4667/4885
US-20040186145-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them GUCY1A1, GUCY1B1, GUCY1A2 KMT2A 4203/4885MEN1 3056/4885MAPT 4873/4885
US-10189809-B2 SGC stimulators GUCY1A1, PTGIS, GUCY1B1 KMT2A 4149/4885MEN1 3461/4885MAPT 4837/4885
US-20230381153-A1 TREATMENT OF CNS DISEASES WITH sGC STIMULATORS GUCY1A2, GUCY1B2, PDE2A KMT2A 3687/4885MEN1 1983/4885MAPT 3160/4885
US-20140288079-A1 SGC STIMULATORS OF SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION PDE5A, PDE3B, PDE3A KMT2A 3465/4885MEN1 3180/4885MAPT 4395/4885
US-10844064-B2 sGC stimulators GUCY1B1, GUCY1A1, PRKG1 KMT2A 2901/4885MEN1 3638/4885MAPT 4862/4885
US-20130123354-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS GUCY1A2, GUCY1B2, GUCY1B1 KMT2A 3747/4885MEN1 3134/4885MAPT 3732/4885
US-20190125709-A1 STIMULATORS AND/OR ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE (SGC) IN COMBINATION WITH AN INHIBITOR OF NEUTRAL ENDOPEPTIDASE (NEP INHIBITOR) AND/OR AN ANGIOTENSIN AII ANTAGONIST AND THE USE THEREOF MME, ECE1, REN KMT2A 4141/4885MEN1 3303/4885MAPT 3217/4885
US-10183021-B2 sGC stimulators PTGIS, CGAS, GUCY1A1 KMT2A 4250/4885MEN1 2447/4885MAPT 4849/4885
US-10927136-B2 Phosphorus prodrugs of pyrazolo-substituted pyrimidine sGC stimulators P2RY1, P2RY11, GMPS KMT2A 3918/4885MEN1 2409/4885MAPT 4814/4885
US-10189856-B2 Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) PDE5A, PDE3A, PDE2A KMT2A 4014/4885MEN1 4136/4885MAPT 4846/4885
US-11572358-B2 Solid forms of an sGC stimulator GUCY1A2, PRKG1, GUCY1A1 KMT2A 4389/4885MEN1 2771/4885MAPT 4405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.