Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5154776 | 0.90 | ADRA2C (0.55) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL17473048 | 0.88 | NPC1 (0.57) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL30957362 | 0.88 | NPC1 (0.57) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL7791465 | 0.88 | HDAC3 (0.51) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL7139664 | 0.85 | ADRA2C (0.51) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL2892022 | 0.82 | NPC1 (0.61) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL14488322 | 0.82 | ADRA2C (0.45) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL894066 | 0.81 | NPC1 (0.69) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL7995028 | 0.79 | NPC1 (0.71) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL5509984 | 0.79 | NPC1 (0.71) | ADRA2CSMN1; SMN2MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | ADRA2C 1067/4885SMN1; SMN2 2665/4885MEN1 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.