Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 6/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9154589 | 0.80 | LTA4H (0.79) | LTA4HEPHX2BCHEOPRM1OPRD1 | |
| SCHEMBL9081140 | 0.79 | LTA4H (0.82) | LTA4HEPHX2BCHEOPRM1OPRD1 | |
| SCHEMBL8499156 | 0.79 | LTA4H (0.82) | LTA4HEPHX2BCHEOPRM1OPRD1 | |
| SCHEMBL8810102 | 0.74 | LTA4H (0.94) | LTA4HEPHX2BCHEOPRM1OPRD1 | |
| SCHEMBL10098558 | 0.74 | LTA4H (0.68) | LTA4HEPHX2BCHEOPRM1OPRD1 | |
| SCHEMBL579810 | 0.74 | LTA4H (0.68) | LTA4HEPHX2BCHEOPRM1OPRD1 | |
| SCHEMBL11881258 | 0.73 | GAA (0.91) | LTA4HEPHX2BCHEGAAMAPT | |
| SCHEMBL3272134 | 0.73 | GAA (0.91) | LTA4HEPHX2BCHEGAAMAPT | |
| SCHEMBL27228 | 0.72 | GAA (0.95) | BCHEGAAMAPTMEN1KMT2A | |
| SCHEMBL14201268 | 0.71 | OPRM1 (0.65) | LTA4HEPHX2BCHEOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338611-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2012-12-25 | — | — | US | disclosed |
| US-20080207701-A1 | OPIOID RECEPTOR ANTAGONISTS | CHAPPELL MARK DONALD | 2008-08-28 | — | — | US | disclosed |
| US-7378448-B2 | Diphenylether amide derivatives as opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-05-27 | — | — | US | disclosed |
| US-20070066658-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207701-A1 | OPIOID RECEPTOR ANTAGONISTS | OPRD1, OPRM1, OPRK1 | LTA4H 2224/4885EPHX2 2120/4885BCHE 1305/4885 |
| US-20070066658-A1 | OPIOID RECEPTOR ANTAGONISTS | OPRD1, OPRM1, OPRK1 | LTA4H 2224/4885EPHX2 2120/4885BCHE 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.