Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632720 | 0.78 | MCOLN3 (0.61) | SMN1; SMN2GAACACNA1BNR1I2NR1H3 | |
| SCHEMBL3724224 | 0.75 | CA12 (0.43) | NPSR1MAPTNR1H3RORCMEN1 | |
| SCHEMBL27879694 | 0.74 | RORC (0.41) | SMN1; SMN2LMNAPOLBRAB9ARORC | |
| SCHEMBL4928804 | 0.74 | MAPK1 (0.43) | SMN1; SMN2LMNAGAATP53MAPT | |
| SCHEMBL27500836 | 0.67 | MEN1 (0.42) | SMN1; SMN2GAAPOLBMEN1ALDH1A1 | |
| SCHEMBL18586243 | 0.67 | GAA (0.35) | SMN1; SMN2GAANPSR1POLBRAB9A | |
| SCHEMBL4926815 | 0.67 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAGAANPSR1MAPT | |
| SCHEMBL1498496 | 0.67 | HTR6 (0.44) | CACNA1BNR1I2POLBRAB9ACYP3A4 | |
| SCHEMBL3836513 | 0.67 | CCR5 (0.41) | SMN1; SMN2LMNAPOLBMEN1ALDH1A1 | |
| SCHEMBL13900682 | 0.66 | RORC (0.49) | SMN1; SMN2LMNAGAANPSR1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188659-A1 | Method for Preparing Halogenated Amines | WYETH (US) | 2008-08-07 | — | — | US | disclosed |
| US-20080188659-A1 | Method for Preparing Halogenated Amines | WYETH (US) | 2008-08-07 | — | — | US | disclosed |
| US-20080188659-A1 | Method for Preparing Halogenated Amines | WYETH (US) | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188659-A1 | Method for Preparing Halogenated Amines | PNMT, ABL1, INMT | SMN1; SMN2 3833/4885LMNA 1481/4885GAA 2501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.