Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | SPPL2B | Q8TCT7 | 1/20 | 0.38 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SLC9A3 | P48764 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493855 | 0.93 | BDKRB1 (0.41) | BDKRB1CXCR3PSEN1PSEN2APH1B | |
| SCHEMBL493086 | 0.93 | BDKRB1 (0.42) | BDKRB1CXCR3PSEN1PSEN2APH1B | |
| SCHEMBL492782 | 0.92 | CXCR3 (0.47) | BDKRB1CXCR3PSEN1PSEN2APH1B | |
| SCHEMBL493519 | 0.92 | LMNA (0.40) | CXCR3ALDH1A1LMNASLC9A3PKM | |
| SCHEMBL493165 | 0.91 | SMN1; SMN2 (0.41) | CXCR3ALDH1A1LMNASLC9A3PKM | |
| SCHEMBL493376 | 0.90 | ALDH1A1 (0.38) | CXCR3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL492871 | 0.90 | ALDH1A1 (0.38) | CXCR3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL493177 | 0.89 | ALDH1A1 (0.38) | CXCR3ALDH1A1LMNASLC9A3PKM | |
| SCHEMBL492721 | 0.88 | CXCR3 (0.43) | CXCR3ALDH1A1LMNAPKMMEN1 | |
| SCHEMBL493168 | 0.88 | CXCR3 (0.41) | BDKRB1CXCR3PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | claimed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | BDKRB1 1622/4885CXCR3 4458/4885PSEN1 3663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.