Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 3/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493217 | 0.88 | GCGR (0.49) | MMEHDAC4HDAC6ALDH1A1GSK3B | |
| SCHEMBL494459 | 0.82 | HDAC4 (0.50) | HDAC4HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL493785 | 0.81 | CYP2C19 (0.41) | CYP2C19RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL493024 | 0.80 | CYP2C19 (0.47) | MMECYP2C19NPC1RAB9AKMT2A | |
| SCHEMBL493603 | 0.80 | KMT2A (0.44) | KMT2ASMN1; SMN2KDM4EMAPTEGLN1 | |
| SCHEMBL28816298 | 0.78 | ALPL (0.50) | HDAC4HDAC6NPC1RAB9AALDH1A1 | |
| SCHEMBL28816278 | 0.74 | HTT (0.56) | HDAC4HDAC6NPC1RAB9AKMT2A | |
| SCHEMBL493104 | 0.74 | POLB (0.46) | KMT2AEGLN1VEGFAFLT1GSK3B | |
| SCHEMBL493192 | 0.73 | NPC1 (0.56) | NPC1RAB9AKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL493401 | 0.72 | ALDH1A1 (0.42) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | SHMT1 4438/4885SHMT2 4453/4885MME 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.