Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.41 |
| ▸ | THRA | P10827 | 18/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717861 | 0.91 | THRA (0.36) | THRBTHRA | |
| SCHEMBL4928285 | 0.91 | THRB (0.40) | THRBTHRA | |
| SCHEMBL4930388 | 0.91 | THRB (0.43) | THRBTHRAABCB11PTGS1PTGS2 | |
| SCHEMBL4931430 | 0.90 | THRA (0.40) | THRBTHRA | |
| SCHEMBL4927497 | 0.90 | THRB (0.48) | THRBTHRA | |
| SCHEMBL5103433 | 0.86 | THRA (0.54) | THRBTHRAABCB11PTGS1PTGS2 | |
| SCHEMBL4922939 | 0.85 | THRB (0.40) | THRBTHRAABCB11PTGS1PTGS2 | |
| SCHEMBL4926366 | 0.85 | THRB (0.41) | THRBTHRAABCB11PTGS1PTGS2 | |
| SCHEMBL4935198 | 0.85 | ALDH1A1 (0.38) | THRB | |
| SCHEMBL5717856 | 0.84 | THRB (0.38) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | KARO BIO AB (SE) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | TSHR, TRHR, THRA | THRB 4/4885THRA 3/4885ABCB11 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.