Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493720 | 0.92 | RAB9A (0.46) | MEN1KMT2APOLBALDH1A1FKBP1A | |
| SCHEMBL493738 | 0.89 | RAB9A (0.43) | MEN1KMT2APOLBGAAPAX8 | |
| SCHEMBL492898 | 0.88 | FKBP1A (0.42) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL492665 | 0.87 | HSD11B1 (0.39) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL494049 | 0.87 | MEN1 (0.35) | MEN1KMT2ACCR4POLBGAA | |
| SCHEMBL493222 | 0.84 | SMN1; SMN2 (0.44) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL492515 | 0.84 | RAB9A (0.49) | MEN1KMT2APOLBALDH1A1FKBP1A | |
| SCHEMBL492818 | 0.84 | NPC1 (0.49) | MEN1KMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL493108 | 0.84 | GAA (0.42) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL492696 | 0.83 | NPC1 (0.44) | KMT2APOLBALDH1A1BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | PSEN1 3663/4885PSEN2 2905/4885APH1B 1166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.