Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4927214 | 0.86 | KEAP1 (0.68) | SMN1; SMN2NPC1ALDH1A1LMNAPOLB | |
| SCHEMBL4934333 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1KEAP1NFE2L2PTPN1 | |
| SCHEMBL4930553 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1ALDH1A1LMNAPOLB | |
| SCHEMBL4935879 | 0.81 | KEAP1 (0.65) | SMN1; SMN2NPC1ALDH1A1POLBRAB9A | |
| SCHEMBL4930713 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL4934228 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1ALDH1A1LMNAPOLB | |
| SCHEMBL4933383 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1POLBRAB9AKEAP1 | |
| SCHEMBL3366742 | 0.77 | KEAP1 (0.77) | LMNAKEAP1NFE2L2 | |
| SCHEMBL697566 | 0.75 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HTT | |
| SCHEMBL16384049 | 0.75 | ALDH1A1 (0.81) | SMN1; SMN2NPC1ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227858-A1 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED | 2008-09-18 | — | — | US | disclosed |
| US-20080227858-A1 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED | 2008-09-18 | — | — | US | disclosed |
| US-20080227858-A1 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED | 2008-09-18 | — | — | US | disclosed |
| US-7375248-B2 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED (GB) | 2008-05-20 | — | — | US | disclosed |
| US-7375248-B2 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED (GB) | 2008-05-20 | — | — | US | disclosed |
| US-7375248-B2 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED (GB) | 2008-05-20 | — | — | US | disclosed |
| US-20060142385-A1 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | US | disclosed |
| WO-2004113279-A1 | INHIBITORS OF MATRIX METALLOPROTEINASE | GLAXO GROUP LIMITED (GB) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142385-A1 | Inhibitors of matrix metalloproteinase | MMP9, MMP13, MMP26 | SMN1; SMN2 3337/4885NPC1 3253/4885ALDH1A1 3385/4885 |
| US-20080227858-A1 | Inhibitors of matrix metalloproteinase | MMP9, MMP13, MMP2 | SMN1; SMN2 3365/4885NPC1 3274/4885ALDH1A1 3221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.