Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134605 | 0.87 | MRGPRX4 (0.41) | MRGPRX4KDM4EALDH1A1MAPTTP53 | |
| SCHEMBL4934741 | 0.76 | MRGPRX4 (0.44) | MRGPRX4KDM4EALDH1A1MAPTTP53 | |
| SCHEMBL15808955 | 0.74 | MRGPRX4 (0.53) | MRGPRX4KDM4EALDH1A1MAPTTP53 | |
| SCHEMBL4134602 | 0.72 | L3MBTL1 (0.45) | MRGPRX4ALDH1A1TP53CYP4F2CYP4A11 | |
| SCHEMBL15808806 | 0.72 | MRGPRX4 (0.57) | MRGPRX4KDM4EALDH1A1MAPTTP53 | |
| SCHEMBL15808726 | 0.67 | MRGPRX4 (0.45) | MRGPRX4KDM4EALDH1A1MAPTTP53 | |
| SCHEMBL1671704 | 0.67 | PTGES (0.59) | — | |
| SCHEMBL21510776 | 0.66 | RARB (0.51) | KDM4EALDH1A1TDP1 | |
| SCHEMBL15809160 | 0.65 | MRGPRX4 (0.48) | MRGPRX4KDM4EALDH1A1MAPTTP53 | |
| SCHEMBL6235212 | 0.65 | IDO1 (0.45) | NPSR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139636-A1 | Adamantane derivatives | ASTRAZENECA AB. | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139636-A1 | Adamantane derivatives | ADAM33, ADAM17, BACE1 | MRGPRX4 2407/4885KDM4E 3146/4885ALDH1A1 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.