Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237097 | 0.84 | LMNA (0.48) | IDO1NPC1RAB9A | |
| SCHEMBL6240427 | 0.82 | CYP3A4 (0.46) | IDO1TSHR | |
| SCHEMBL6235218 | 0.80 | SIGMAR1 (0.64) | IDO1SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9618230 | 0.79 | CYP1A2 (0.53) | IDO1TSHRSIGMAR1MEN1KMT2A | |
| SCHEMBL6237705 | 0.78 | RAB9A (0.45) | SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL6239312 | 0.78 | SMN1; SMN2 (0.52) | TSHRMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL5653389 | 0.77 | TSHR (0.54) | TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6244574 | 0.76 | IDO1 (0.44) | IDO1MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6237989 | 0.75 | IDO1 (0.49) | IDO1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6239811 | 0.73 | SIRT2 (0.49) | TSHRMEN1KMT2ARAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |