Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134602 | 0.87 | L3MBTL1 (0.45) | MRGPRX4CYP4F2CYP4A11ALDH1A1TP53 | |
| SCHEMBL4934744 | 0.76 | MRGPRX4 (0.43) | MRGPRX4CYP4F2CYP4A11ALDH1A1TP53 | |
| SCHEMBL15808955 | 0.75 | MRGPRX4 (0.53) | MRGPRX4CYP4F2CYP4A11ALDH1A1TP53 | |
| SCHEMBL15808806 | 0.73 | MRGPRX4 (0.57) | MRGPRX4CYP4F2CYP4A11ALDH1A1TP53 | |
| SCHEMBL4134605 | 0.73 | MRGPRX4 (0.41) | MRGPRX4CYP4F2CYP4A11ALDH1A1TP53 | |
| SCHEMBL4134985 | 0.69 | P2RX7 (0.58) | — | |
| SCHEMBL14969145 | 0.69 | HTR2C (0.43) | MRGPRX4CYP4F2CYP4A11ALDH1A1TP53 | |
| SCHEMBL14966097 | 0.69 | CYP4F2 (0.46) | CYP4F2CYP4A11ALDH1A1KDM4EMAPT | |
| SCHEMBL15808726 | 0.68 | MRGPRX4 (0.45) | MRGPRX4CYP4F2CYP4A11ALDH1A1TP53 | |
| SCHEMBL27626651 | 0.67 | ALDH1A1 (0.52) | MRGPRX4CYP4F2CYP4A11ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139636-A1 | Adamantane derivatives | ASTRAZENECA AB. | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139636-A1 | Adamantane derivatives | ADAM33, ADAM17, BACE1 | MRGPRX4 2407/4885CYP4F2 1352/4885CYP4A11 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.