Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 5/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | MTTP | P55157 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493708 | 0.85 | KMT2A (0.39) | SMN1; SMN2LMNAKMT2AMAPTMTTP | |
| SCHEMBL493863 | 0.82 | LMNA (0.48) | HDAC4HDAC6SMN1; SMN2LMNAKMT2A | |
| SCHEMBL493621 | 0.79 | CYP2D6 (0.45) | SMN1; SMN2NPC1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL493256 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAKMT2APKMMAPT | |
| SCHEMBL1327459 | 0.76 | MCHR1 (0.51) | HDAC6KMT2AOPRM1OPRL1MEN1 | |
| SCHEMBL494420 | 0.76 | LMNA (0.46) | HDAC4HDAC6SMN1; SMN2LMNAKMT2A | |
| SCHEMBL493647 | 0.75 | KDM4E (0.48) | HDAC4SMN1; SMN2LMNAKMT2APKM | |
| SCHEMBL4231730 | 0.74 | RAB9A (0.41) | SMN1; SMN2LMNAMAPTSIRT2NPC1 | |
| SCHEMBL1327796 | 0.73 | OPRL1 (0.43) | HDAC4OPRM1OPRL1 | |
| SCHEMBL493393 | 0.73 | OPRL1 (0.44) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | claimed |