Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 6/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493461 | 0.94 | KDM4E (0.45) | LMNAPKMKMT2ASMN1; SMN2MAPT | |
| SCHEMBL493863 | 0.89 | LMNA (0.48) | LMNAPKMKMT2ASMN1; SMN2MAPT | |
| SCHEMBL493647 | 0.82 | KDM4E (0.48) | LMNAPKMKMT2ASMN1; SMN2MAPT | |
| SCHEMBL493591 | 0.81 | SMN1; SMN2 (0.47) | LMNAPKMKMT2ASMN1; SMN2MAPT | |
| SCHEMBL493779 | 0.79 | SMN1; SMN2 (0.52) | LMNAPKMKMT2ASMN1; SMN2MAPT | |
| SCHEMBL493514 | 0.76 | HDAC4 (0.44) | LMNAPKMKMT2ASMN1; SMN2MAPT | |
| SCHEMBL493737 | 0.75 | KMT2A (0.49) | KMT2AMAPT | |
| SCHEMBL492980 | 0.75 | KDM4E (0.45) | LMNAPKMKMT2ASMN1; SMN2MAPT | |
| SCHEMBL492913 | 0.74 | RAB9A (0.39) | KMT2ASMN1; SMN2MAPTCCR2NPC1 | |
| SCHEMBL494415 | 0.73 | TSHR (0.42) | PKMKMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | claimed |