Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24157932 | 0.88 | ALDH1A1 (0.33) | ALDH1A1GAATDP1TSHR | |
| SCHEMBL11232780 | 0.86 | ALDH1A1 (0.39) | ALDH1A1GAATDP1TSHRLMNA | |
| SCHEMBL12561149 | 0.82 | KDM4E (0.45) | ALDH1A1GAATDP1TSHRLMNA | |
| SCHEMBL12301948 | 0.81 | ALDH1A1 (0.35) | ALDH1A1GAATDP1TSHRLMNA | |
| SCHEMBL12410508 | 0.80 | NAALAD2 (0.43) | ALDH1A1TDP1TSHRLMNASLC15A2 | |
| SCHEMBL4847615 | 0.80 | ALDH1A1 (0.43) | ALDH1A1GAATDP1TSHRLMNA | |
| SCHEMBL17445680 | 0.78 | TSHR (0.36) | ALDH1A1TDP1TSHR | |
| SCHEMBL12602055 | 0.78 | TSHR (0.55) | ALDH1A1GAATDP1TSHRLMNA | |
| SCHEMBL9868805 | 0.76 | ALDH1A1 (0.35) | ALDH1A1TDP1TSHR | |
| SCHEMBL9868811 | 0.76 | ALDH1A1 (0.35) | ALDH1A1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | GRUENENTHAL GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
| WO-2016008583-A1 | SUBSTITUTED AZA-SPIRO(4.5)DECAN-DERIVATIVES | Grünenthal GmbH (DE) | 2016-01-21 | — | — | WO | disclosed |
| US-20110152259-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | PALANI ANANDAN | 2011-06-23 | — | — | US | disclosed |
| US-20080182994-A1 | Crystal of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid and process for producing the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2008-07-31 | — | — | US | disclosed |
| US-20060205801-A1 | Crystal and process for producing the same | HASHIMOTO HIDEO | 2006-09-14 | — | — | US | disclosed |
| US-7067546-B2 | Crystal and process for producing the same | TAKEDA PHARMACEUTICAL COMPANY (JP) | 2006-06-27 | — | — | US | disclosed |
| US-20040215023-A1 | Crystal and process for producing the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-10-28 | — | — | US | disclosed |
| EP-1420016-A1 | CRYSTAL AND PROCESS FOR PRODUCING THE SAME | Takeda Chemical Industries, Ltd. (JP) | 2004-05-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205801-A1 | Crystal and process for producing the same | RCC1, RCC2, NPM1 | ALDH1A1 1641/4885GAA 3606/4885TDP1 2560/4885 |
| US-20080182994-A1 | Crystal of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid and process for producing the same | BRD7, BMI1, ALK | ALDH1A1 800/4885GAA 3360/4885TDP1 2486/4885 |
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | OPRL1, OPRD1, OPRM1 | ALDH1A1 386/4885GAA 4184/4885TDP1 4479/4885 |
| US-20110152259-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | CYP11B2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP11B1 | ALDH1A1 1177/4885GAA 1668/4885TDP1 1414/4885 |
| US-20040215023-A1 | Crystal and process for producing the same | SBDS, RCC1, RCC2 | ALDH1A1 1224/4885GAA 2693/4885TDP1 3385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.