Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84337 | 0.79 | POLB (0.66) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27712068 | 0.78 | POLB (0.64) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6141396 | 0.77 | POLB (0.68) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10089770 | 0.77 | ALDH1A1 (0.62) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14612413 | 0.76 | POLB (0.66) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3524765 | 0.76 | POLB (0.66) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL19750673 | 0.76 | ALDH1A1 (0.60) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL15480586 | 0.75 | ALDH1A1 (0.60) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4940110 | 0.75 | LMNA (0.60) | ALDH1A1POLBSMN1; SMN2TP53PKM | |
| SCHEMBL19749246 | 0.75 | ALDH1A1 (0.60) | ALDH1A1POLBSMN1; SMN2TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114041-A1 | Benzothiazolesulfonamides | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | US | claimed |
| US-20080114041-A1 | Benzothiazolesulfonamides | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | US | disclosed |
| US-20080114041-A1 | Benzothiazolesulfonamides | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | US | disclosed |
| US-20080114041-A1 | Benzothiazolesulfonamides | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | US | disclosed |
| EP-1833808-A1 | NEW BENZOTHIAZOLESULFONAMIDES | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006068593-A1 | NEW BENZOTHIAZOLESULFONAMIDES | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114041-A1 | Benzothiazolesulfonamides | SULT1E1, TST, SULT1A1 | ALDH1A1 382/4885POLB 3863/4885SMN1; SMN2 2496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.