Sugi Predict

Sugi Predict / Compounds / SCHEMBL4941863

SCHEMBL4941863

SCHEMBL4941863

CC(C)(C)OC(=O)N1CCN(c2c(F)cc(C=O)cc2F)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 5/20 0.47
▸ ALDH1A1 P00352 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ MAPT P10636 1/20 0.44
▸ PDK2 Q15119 1/20 0.44
▸ SMARCA2 P51531 1/20 0.42
▸ SMARCA4 P51532 1/20 0.42
▸ PBRM1 Q86U86 1/20 0.42
▸ F13A1 P00488 1/20 0.42
▸ TGM2 P21980 1/20 0.42
▸ TGM1 P22735 1/20 0.42
▸ DPP4 P27487 1/20 0.41
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ POLB P06746 1/20 0.40
▸ USP2 O75604 1/20 0.40
▸ CKS1B P61024 1/20 0.40
▸ SKP1 P63208 1/20 0.40
▸ SKP2 Q13309 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL355504 0.87 ALDH1A1 (0.58) GPR119ALDH1A1LMNAMAPTPDK2
SCHEMBL30479010 0.87 ALDH1A1 (0.58) GPR119ALDH1A1LMNAMAPTPDK2
SCHEMBL24215767 0.86 GPR119 (0.47) GPR119ALDH1A1LMNAMAPTPDK2
SCHEMBL17422197 0.85 GPR119 (0.53) GPR119ALDH1A1LMNAMAPTPDK2
SCHEMBL2445935 0.84 GPR119 (0.49) GPR119ALDH1A1LMNAMAPTPDK2
SCHEMBL24606792 0.84 GPR119 (0.49) GPR119ALDH1A1LMNAMAPTPDK2
SCHEMBL20235011 0.83 GPR119 (0.48) GPR119ALDH1A1LMNAMAPTPDK2
SCHEMBL18879712 0.82 GPR119 (0.44) GPR119ALDH1A1LMNAMAPTPDK2
SCHEMBL23086870 0.82 GPR119 (0.51) GPR119PDK2SMARCA2SMARCA4PBRM1
SCHEMBL20231293 0.81 GPR119 (0.47) GPR119ALDH1A1LMNAMAPTPDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250034152-A1 METHOD FOR PREPARING TRIAZOLOPYRIMIDINONE DERIVATIVE ST PHARM CO., LTD. (KR) 2025-01-30 — — US disclosed
EP-4442687-A1 METHOD FOR PREPARING TRIAZOLOPYRIMIDINONE DERIVATIVE ST Pharm Co., Ltd. (KR) 2024-10-09 — — EP disclosed
CN-118284609-A Process for preparing triazolopyrimidinone derivatives ST制药株式会社 2024-07-02 — — CN disclosed
CN-116261458-B PLK1 degradation inducing compounds 厄普特拉株式会社 2024-05-24 — — CN disclosed
US-11939334-B2 Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers UPPTHERA, INC. (KR) 2024-03-26 — — US disclosed
US-20230242541-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2023-08-03 — — US disclosed
US-20230242541-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2023-08-03 — — US disclosed
US-20230242541-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2023-08-03 — — US disclosed
CN-116261458-A Novel PLK1 degradation inducing compounds 厄普特拉株式会社 2023-06-13 — — CN disclosed
WO-2023101048-A1 METHOD FOR PREPARING TRIAZOLOPYRIMIDINONE DERIVATIVE 에스티팜 주식회사 2023-06-08 — — WO disclosed
WO-2023017446-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2023-02-16 — — WO disclosed
CN-108473504-B Novel dihydropyranopyrimidinone derivatives and uses thereof ST制药株式会社 2021-04-16 — — CN disclosed
US-20170145016-A1 NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF ST PHARM CO., LTD. (KR) 2017-05-25 — — US disclosed
US-20130345215-A1 PYRAZOLOPYRIMIDONE AND PYRAZOLOPYRIDONE INHIBITORS OF TANKYRASE F. HOFFMANN-LA ROCHE AG (CH) 2013-12-26 — — US disclosed
US-20080255144-A1 Acylated Piperidines as Glycine Transporter Inhibitors GLAXO GROUP LIMITED 2008-10-16 — — US disclosed
US-20080255144-A1 Acylated Piperidines as Glycine Transporter Inhibitors GLAXO GROUP LIMITED 2008-10-16 — — US disclosed
US-20080255144-A1 Acylated Piperidines as Glycine Transporter Inhibitors GLAXO GROUP LIMITED 2008-10-16 — — US disclosed
EP-1858869-A1 ACYLATED PIPERIDINES AS GLYCINE TRANSPORTER INHIBITORS GLAXO GROUP LIMITED (GB) 2007-11-28 — — EP disclosed
WO-2006094842-A1 ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS GLAXO GROUP LIMITED (GB) 2006-09-14 — — WO disclosed
WO-2006094842-A1 ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS GLAXO GROUP LIMITED (GB) 2006-09-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080255144-A1 Acylated Piperidines as Glycine Transporter Inhibitors SLC1A1, SLC6A7, SLC1A2 GPR119 329/4885ALDH1A1 1291/4885LMNA 4248/4885
US-20170145016-A1 NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF TNKS1BP1, TNKS, TPI1 GPR119 2608/4885ALDH1A1 2244/4885LMNA 3055/4885
US-11939334-B2 Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers PLK1, BUB1B, BUB1 GPR119 4626/4885ALDH1A1 2752/4885LMNA 1899/4885
US-20130345215-A1 PYRAZOLOPYRIMIDONE AND PYRAZOLOPYRIDONE INHIBITORS OF TANKYRASE TNKS1BP1, TPI1, TNKS GPR119 3809/4885ALDH1A1 953/4885LMNA 4478/4885
US-20230242541-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND PLK1, BUB1B, BUB1 GPR119 4495/4885ALDH1A1 4008/4885LMNA 2201/4885
US-20250034152-A1 METHOD FOR PREPARING TRIAZOLOPYRIMIDINONE DERIVATIVE TNKS1BP1, TNKS, TPI1 GPR119 3469/4885ALDH1A1 1918/4885LMNA 3736/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.