Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.33 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.32 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL5874734 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL30358483 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL4944913 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL6479985 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL5875419 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL14989224 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL6838017 | 0.97 | TSHR (0.47) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL28088241 | 0.95 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL27950677 | 0.89 | ALDH1A1 (0.41) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL1131856 | 0.85 | ALDH1A1 (0.50) | ALDH1A1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119707347-A | Polymer cement grinding aid and preparation method thereof | 杭州砺品科技有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-116143439-B | Preparation method of novel cement grinding aid | 宜春红狮水泥有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119465151-A | Preparation method of metal etching liquid | 熙腾电子科技（上海）有限公司 | 2025-02-18 | — | — | CN | claimed |
| CN-118459135-A | Preparation method of modified metallurgical waste slag powder, low-carbon high-temperature-resistant ultra-high-performance concrete and preparation method thereof | 江苏苏博特新材料股份有限公司 | 2024-08-09 | — | — | CN | claimed |
| CN-115959844-B | Method for preparing cement by using phosphogypsum | 康达(湖南)水泥有限公司 | 2024-07-26 | — | — | CN | claimed |
| CN-118005343-A | Light ultra-high performance concrete for bridge engineering and preparation method thereof | 中交二航武汉港湾新材料有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-117024029-A | Composite early strength admixture and preparation method and application thereof | 中建西部建设建材科学研究院有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-116622318-B | Preparation method of low-shrinkage ether-based epoxy sealant | 山东凯恩新材料科技有限公司 | 2023-09-12 | — | — | CN | claimed |
| CN-116622318-A | Preparation method of low-shrinkage ether-based epoxy sealant | 山东凯恩新材料科技有限公司 | 2023-08-22 | — | — | CN | claimed |
| CN-116554224-A | Method for preparing difluoro sodium bisoxalate phosphate by using fluorine-containing solvent | 衢州市九洲化工有限公司 | 2023-08-08 | — | — | CN | claimed |
| CN-107602023-B | Large-mixing-amount fly ash concrete and preparation method thereof | 南京建高新材料科技有限公司 | 2020-05-26 | — | — | CN | claimed |
| CN-110963738-A | Method for reducing water absorption of aerated concrete | 河海大学 | 2020-04-07 | — | — | CN | claimed |
| CN-110204451-A | A kind of additive and preparation method thereof improving nickel slag early activity index | 北京工业大学 | 2019-09-06 | — | — | CN | claimed |
| CN-109970927-A | A kind of high-thin arch dam ultra early-strength polycarboxylate water-reducer and preparation method thereof | 四川同舟化工科技有限公司 | 2019-07-05 | — | — | CN | claimed |
| CN-109399999-A | A kind of high early-strength low-alkali liquid quick-setting agent of green and preparation method | 江苏奥莱特新材料股份有限公司 | 2019-03-01 | — | — | CN | claimed |
| CN-109134784-A | It is a kind of to promote solidifying high-early strength polyocarboxy acid superplasticiser and preparation method thereof | 刘翠芬 | 2019-01-04 | — | — | CN | claimed |
| CN-106565122-B | Mcromolecular grinding aid and its preparation method and application | 同济大学 | 2018-12-18 | — | — | CN | claimed |
| CN-107602023-A | A kind of high volume fly ash concrete and preparation method thereof | 南京建高新材料科技有限公司 | 2018-01-19 | — | — | CN | claimed |
| CN-106565122-A | Polymeric grinding aid, and preparation method and application thereof | 同济大学 | 2017-04-19 | — | — | CN | claimed |
| CN-106396454-A | Slag grinding aid and preparation method and application thereof | 同济大学 | 2017-02-15 | — | — | CN | claimed |