Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.33 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.32 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL30358483 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL4944905 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL4944913 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL6479985 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL5875419 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL14989224 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL6838017 | 0.97 | TSHR (0.47) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL28088241 | 0.95 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL27950677 | 0.89 | ALDH1A1 (0.41) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL1131856 | 0.85 | ALDH1A1 (0.50) | ALDH1A1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240138403-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2024-05-02 | — | — | US | claimed |
| CN-114956653-B | Coordination activator, liquid alkali-free accelerator and preparation method and application thereof | 山西佳维新材料股份有限公司 | 2023-02-28 | — | — | CN | claimed |
| US-20230021295-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2023-01-19 | — | — | US | claimed |
| WO-2023278670-A1 | SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES | ETHOX CHEMICALS, LLC (US) | 2023-01-05 | — | — | WO | claimed |
| CN-113912321-B | Coordination activator, liquid alkali-free accelerator and preparation method and application thereof | 山西佳维新材料股份有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-114956653-A | Coordination activator, liquid alkali-free accelerator and preparation method and application thereof | 山西佳维新材料股份有限公司 | 2022-08-30 | — | — | CN | claimed |
| CN-110078910-B | Branched polyether monomer for polycarboxylic acid water reducing agent and synthesis method thereof | 福建钟山化工有限公司 | 2022-03-04 | — | — | CN | claimed |
| CN-113912321-A | Coordination activator, liquid alkali-free accelerator and preparation method and application thereof | 山西佳维新材料股份有限公司 | 2022-01-11 | — | — | CN | claimed |
| US-20240138403-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2024-05-02 | — | — | US | disclosed |
| CN-114956653-B | Coordination activator, liquid alkali-free accelerator and preparation method and application thereof | 山西佳维新材料股份有限公司 | 2023-02-28 | — | — | CN | disclosed |
| US-20230021295-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2023-01-19 | — | — | US | disclosed |
| WO-2023278670-A1 | SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES | ETHOX CHEMICALS, LLC (US) | 2023-01-05 | — | — | WO | disclosed |
| CN-113912321-B | Coordination activator, liquid alkali-free accelerator and preparation method and application thereof | 山西佳维新材料股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-114956653-A | Coordination activator, liquid alkali-free accelerator and preparation method and application thereof | 山西佳维新材料股份有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-108003305-B | Synthetic method of polycarboxylate superplasticizer | 北京砼帮汇科技有限公司 | 2020-11-03 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-5200493-A | Polyurethanes and polythiourethanes; protective coatings; oil repellents; waterproofing; antisoilants | CIBA-GEIGY CORPORATION (US) | 1993-04-06 | — | — | US | disclosed |
| US-5145996-A | Waterproofing coatings for textiles, glass, paper, leather | CIBA-GEIGY CORPORATION (US) | 1992-09-08 | — | — | US | disclosed |
| EP-0501915-A1 | Heteroatom containing perfluoroalkyl terminated neopentyl mercapto-alcohols and compositions therefrom | CIBA-GEIGY AG (CH) | 1992-09-02 | — | — | EP | disclosed |