Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.32 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.31 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL4944905 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL14989224 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL4944913 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL6479985 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL5874734 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL30358483 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL5875419 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL28088241 | 0.92 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL27950677 | 0.86 | ALDH1A1 (0.41) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Trolamine SCHEMBL7744499 | 0.83 | ALOX15 (0.44) | TSHRKDM4EALOX15MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6753361-B2 | FINELY DIVIDED MATERIAL IS MIXED OR IMPREGNATED WITH A HEAT-CURABLE FORMULATION AND THE RESULTANT MIXTURE IS SHAPED BY HEATING OR SHEETLIKE STRUCTURE OF FIBER MATERIALS IS FIRST TREATED WITH A HEAT-CURABLE FORMULATION AND THEN HEATED | BASF AKTIENGESELLSCHAFT (DE) | 2004-06-22 | — | — | US | disclosed |
| US-20020130439-A1 | Compositions for producing moldings from finely divided materials | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-19 | — | — | US | disclosed |