Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2518688 | 0.87 | KDM4E (0.46) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3647432 | 0.84 | RAB9A (0.44) | RAB9ACYP11B1CYP11B2F2P2RX7 | |
| SCHEMBL27792151 | 0.82 | PARP1 (0.46) | RAB9ALMNACYP11B1CYP11B2F2 | |
| SCHEMBL22009640 | 0.81 | LMNA (0.47) | RAB9ALMNACYP11B1CYP11B2NPC1 | |
| SCHEMBL28819041 | 0.80 | TDP1 (0.46) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL26698272 | 0.79 | F2 (0.45) | RAB9ALMNACYP11B1CYP11B2F2 | |
| SCHEMBL8151882 | 0.78 | NOS3 (0.42) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL21801447 | 0.78 | L3MBTL1 (0.48) | LMNAF2KMT2AKDM4EALDH1A1 | |
| SCHEMBL27585578 | 0.78 | HTR7 (0.45) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1812084 | 0.78 | P2RX7 (0.53) | RAB9ACYP11B1CYP11B2F2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023226965-A1 | ROCK INHIBITORS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-11-30 | — | — | WO | disclosed |
| CN-116411037-A | Preparation method of azacyclic ester compound | 河南农业大学 | 2023-07-11 | — | — | CN | disclosed |
| EP-3849983-A1 | TRIAZOLO-PYRIMIDINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020052631-A1 | TRIAZOLO-PYRIMIDINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-03-19 | — | — | WO | disclosed |
| CN-105175421-B | Midbody compound and application thereof for synthesis of selective NK-3 receptor antagonists | 欧歌达有限公司 | 2018-07-13 | — | — | CN | disclosed |
| CN-103906750-B9 | Novel chiral N-acyl-5, 6,7, (8-substituted) -tetrahydro- [1, 2,4] triazolo [4, 3-a ] pyrazines as selective NK-3 receptor antagonists, pharmaceutical compositions, methods for use in NK-3 receptor mediated diseases and chiral synthesis thereof | 欧洲筛选有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-103906750-B | Novel chiral N-acyl-5, 6,7, (8-substituted) -tetrahydro- [1, 2,4] triazolo [4, 3-a ] pyrazines as selective NK-3 receptor antagonists, pharmaceutical compositions, methods for use in NK-3 receptor mediated diseases and chiral synthesis thereof | 欧洲筛选有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-105175421-A | Novel chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor mediated disorders and chiral synthesis thereof | EUROSCREEN SA | 2015-12-23 | — | — | CN | disclosed |
| CN-102917588-B | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-08 | — | — | CN | disclosed |
| CN-103906750-A | Novel chiral N-acyl-5, 6,7, (8-substituted) -tetrahydro- [1,2,4] triazolo [4,3-a ] pyrazines as selective NK-3 receptor antagonists, pharmaceutical compositions, methods for use in NK-3 receptor mediated diseases and chiral synthesis thereof | EUROSCREEN SA | 2014-07-02 | — | — | CN | disclosed |
| CN-102414210-A | Substituted imidazo [1,2-a ] pyridine derivatives as beta-secretase inhibitors, pharmaceutical compositions, and methods of use | HIGH POINT PHARMACEUTICALS LLC | 2012-04-11 | — | — | CN | disclosed |
| CN-101675050-A | Purines as cysteine protease inhibitors | GLAXO GROUP LTD | 2010-03-17 | — | — | CN | disclosed |
| EP-1958946-A1 | PYRIDAZINE COMPOUND AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2008-08-20 | — | — | EP | disclosed |
| CN-100345852-C | Quinolinyl-pyrrolopyrazoles | LILLY CO ELI (US) | 2007-10-31 | — | — | CN | disclosed |
| CN-1951939-A | Novel pyrrole derivatives as pharmaceutical agents | LILLY CO ELI (US) | 2007-04-25 | — | — | CN | disclosed |
| CN-1269820-C | Novel pyrrole derivatives as medicaments | LILLY CO ELI (US) | 2006-08-16 | — | — | CN | disclosed |
| CN-1714090-A | Quinolinyl-pyrrolopyrazoles | LILLY CO ELI (US) | 2005-12-28 | — | — | CN | disclosed |
| CN-1511157-A | Novel pyrrole derivatives as medicaments | — | 2004-07-07 | — | — | CN | disclosed |
| CN-1309561-A | Therapeutic agent for erectile dysfunction | MOCHIDA PHARM CO LTD (JP) | 2001-08-22 | — | — | CN | disclosed |