⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592214 | 0.80 | — | — | |
| SCHEMBL11685139 | 0.78 | EGLN1 (0.39) | — | |
| SCHEMBL4280908 | 0.78 | LMNA (0.43) | — | |
| SCHEMBL7769403 | 0.76 | LMNA (0.34) | — | |
| SCHEMBL28639418 | 0.76 | L3MBTL1 (0.40) | — | |
| SCHEMBL7769400 | 0.76 | LMNA (0.34) | — | |
| SCHEMBL2797759 | 0.76 | MMP1 (0.43) | — | |
| SCHEMBL3620058 | 0.76 | — | — | |
| SCHEMBL988057 | 0.74 | LMNA (0.36) | — | |
| SCHEMBL7630141 | 0.74 | L3MBTL1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307718-A1 | POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND | Glenmark Pharmaceuticals S.A. (CH) | 2018-04-18 | — | — | EP | claimed |
| CN-107820489-A | PGES 1 suppresses the polymorph of triazolone compound | 格兰马克药品股份有限公司 | 2018-03-20 | — | — | CN | claimed |
| WO-2016199104-A1 | POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-12-15 | — | — | WO | claimed |
| EP-3307718-B1 | POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND | GLENMARK PHARMACEUTICALS SA (CH) | 2020-12-30 | — | — | EP | disclosed |
| US-10457649-B2 | Polymorphs of a mPGES-1 inhibiting triazolone compound | GLENMARK PHARMACEUTICALS S.A. (CH) | 2019-10-29 | — | — | US | disclosed |
| US-20180370923-A1 | POLYMORPHS OF A mPGES-1 INHIBITING TRIAZOLONE COMPOUND | Ichnos Sciences SA (CH) | 2018-12-27 | — | — | US | disclosed |
| US-10112914-B2 | Polymorphs of a mPGES-1 inhibiting triazolone compound | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-10-30 | — | — | US | disclosed |
| US-20180134671-A1 | POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND | Ichnos Sciences SA (CH) | 2018-05-17 | — | — | US | disclosed |
| EP-3307718-A1 | POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND | Glenmark Pharmaceuticals S.A. (CH) | 2018-04-18 | — | — | EP | disclosed |
| WO-2016199104-A1 | POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-12-15 | — | — | WO | disclosed |
| US-8609610-B2 | Inhibitors of the trypsin-like site of the proteasome and methods of use thereof | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-12-17 | — | — | US | disclosed |
| US-20040092562-A1 | Methods for treating inflammatory conditions or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC. | 2004-05-13 | — | — | US | disclosed |
| EP-1363891-A2 | ANTHRONE DERIVATIVES AND THEIR USE AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-11-26 | — | — | EP | disclosed |
| US-20030073732-A1 | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, INC. | 2003-04-17 | — | — | US | disclosed |
| WO-2002066450-A2 | ANTHRONE DERIVATIVES AND THEIR USE AS INK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-08-29 | — | — | WO | disclosed |
| EP-0054715-A2 | Esters of propanoic acid, preparation of these compounds, weed killers containing these compounds as active ingredients, use of such compounds and compositions for the control of weeds | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-06-30 | — | — | EP | disclosed |
| US-4143034-A | LIGHTFAST | STERLING DRUG INC. (US) | 1979-03-06 | — | — | US | disclosed |
| US-4044153-A | ANTIEDEMIC | MERCK & CO., INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-4029816-A | ANTIHYPERTENSIVE, DIURETIC, SALURETIC | MERCK & CO., INC. (US) | 1977-06-14 | — | — | US | disclosed |
| US-3979361-A | ANTIEDEMA, ANTIINFLAMMATORY | MERCK & CO., INC. (US) | 1976-09-07 | — | — | US | disclosed |