Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | WRN | Q14191 | 1/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 2/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947733 | 0.84 | XDH (0.40) | GSK3AGSK3BSLC22A12MAPT | |
| SCHEMBL4949577 | 0.81 | ALDH1A1 (0.42) | ALDH1A1PLA2G7MAPTMEN1KMT2A | |
| SCHEMBL7020948 | 0.71 | ALDH1A1 (0.57) | ALDH1A1PLA2G7MAPTMEN1POLB | |
| SCHEMBL4950547 | 0.69 | TDP1 (0.47) | — | |
| SCHEMBL4950459 | 0.68 | GRIA2 (0.54) | ALDH1A1PIP4K2APIP4K2BMAPTMEN1 | |
| SCHEMBL27724211 | 0.68 | CYP17A1 (0.43) | GSK3AGSK3BMAPT | |
| SCHEMBL4951186 | 0.65 | ALOX5AP (0.39) | GSK3AGSK3BSLC22A12JAK2MAPT | |
| SCHEMBL4951215 | 0.65 | PTGS2 (0.42) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4949007 | 0.65 | GRM5 (0.36) | — | |
| SCHEMBL4950102 | 0.64 | PTGS1 (0.41) | ALDH1A1MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893597-B1 | AMPA RECEPTOR POTENTIATORS | LILLY CO ELI (US) | 2008-11-12 | — | — | EP | disclosed |