SCHEMBL49520

SCHEMBL49520

C[Si](C)(C)Nc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.48
ALDH1A1 P00352 7/20 0.45
TDP1 Q9NUW8 6/20 0.45
HSD17B10 Q99714 5/20 0.45
CTSD P07339 1/20 0.45
PTGS2 P35354 2/20 0.43
ALOX15 P16050 2/20 0.43
ALOX12 P18054 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
PTGS1 P23219 1/20 0.43
SLC6A2 P23975 1/20 0.43
MAPK1 P28482 1/20 0.43
HTR2B P41595 1/20 0.43
CYP3A4 P08684 4/20 0.41
IDO1 P14902 2/20 0.41
LMNA P02545 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3105010 0.84
SCHEMBL17273060 0.82 TSHR (0.34) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL717181 0.82 TSHR (0.48) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL9181403 0.82 TSHR (0.48) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL11147093 0.80 MAPT (0.42) TSHRALDH1A1TDP1L3MBTL1MAPK1
SCHEMBL9794884 0.79 KCNH3 (0.39) TSHRALDH1A1HSD17B10LMNAHPGD
SCHEMBL6910659 0.78 TSHR (0.43) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL1371114 0.78 TSHR (0.43) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL7691374 0.78 ALDH1A1 (0.53) TSHRALDH1A1TDP1HSD17B10CTSD
SCHEMBL8621518 0.77 HTT (0.39) L3MBTL1TP53EPHX2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 226 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111153931-A 2-pyridine methane imine tin (II) compound and preparation method and application thereof 山西大学 2020-05-15 CN claimed
US-20180135167-A1 Transparent Sheet Materials FUJIFILM MANUFACTURING EUROPE B.V. (NL) 2018-05-17 US claimed
EP-3234216-A2 TRANSPARENT SHEET MATERIALS Fujifilm Manufacturing Europe BV (NL) 2017-10-25 EP claimed
CN-101297038-A Method for prediction of effectiveness of RAR-alpha agonist TAIHO PHARMACEUTICAL CO LTD (JP) 2008-10-29 CN claimed
CN-101137386-A Method for treating liver cancer TAIHO PHARMACEUTICAL CO LTD (JP) 2008-03-05 CN claimed
US-12559452-B2 Method for the synthesis of isocyanates CYNIO GmbH (DE) 2026-02-24 US disclosed
EP-4696723-A1 CONJUGATED DIENE-BASED POLYMER AND RUBBER COMPOSITION COMPRISING THE SAME LG CHEM, LTD. (KR) 2026-02-18 EP disclosed
US-20250346704-A1 Modified Conjugated Diene-Based Polymer, Method for Preparing the Same and Rubber Composition Including the Same LG CHEM, LTD. (KR) 2025-11-13 US disclosed
US-12460033-B2 Modified conjugated diene-based polymer and rubber composition including the same LG CHEM, LTD. (KR) 2025-11-04 US disclosed
EP-4159740-B1 CYCLIC SILAZANE COMPOUND HAVING ALKOXYSILYL GROUP, METHOD FOR PRODUCING SAME, AND COMPOSITION, CURED PRODUCT AND COVERED SUBSTRATE CONTAINING SAME SHINETSU CHEMICAL CO (JP) 2025-10-29 EP disclosed
US-12398231-B2 Modified conjugated diene-based polymer, method for preparing the same and rubber composition including the same LG CHEM, LTD. (KR) 2025-08-26 US disclosed
EP-3950746-B1 MODIFIED CONJUGATED DIENE-BASED POLYMER AND RUBBER COMPOSITION INCLUDING THE SAME LG CHEMICAL LTD (KR) 2025-06-25 EP disclosed
US-4886572-A HAVING POLYMER BONDED TO SPECIFIC CRYSTAL FACE RICOH COMPANY, LTD. (JP) 1989-12-12 US disclosed
EP-0295401-A2 Process for polymerizing polar compounds WACKER-CHEMIE GMBH (DE) 1988-12-21 EP disclosed
EP-0165509-A1 Process for the improvement of the solubility of certain organic compounds which are sparingly soluble in inert solvents by silylation with trialkylsilylcyanide BAYER AG (DE) 1985-12-27 EP disclosed
US-4403099-A Silicon-containing nitro dyes and process for making the same VEB CHEMIEWERK NUNCHRITZ (DD) 1983-09-06 US disclosed
US-4383119-A REAGENTS FOR ORGANIC SYNTHESIS CHEMPLEX COMPANY (US) 1983-05-10 US disclosed
US-4115427-A BY REACTION OF A HYDROGEN SILANE AND AN AMINE DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1978-09-19 US disclosed
US-4059436-A Herbicidal compositions containing silylated chloroacetanilides CIBA-GEIGY CORPORATION (US) 1977-11-22 US disclosed
US-3996254-A Silylated chloroacetanilides for the regulation of plant growth CIBA-GEIGY CORPORATION (US) 1976-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12559452-B2 Method for the synthesis of isocyanates GCN1, SCN7A, GMNN TSHR 2433/4885ALDH1A1 2074/4885TDP1 4468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.