Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404884 | 0.88 | TRPM2 (0.49) | L3MBTL1SMN1; SMN2MAPTKMT2AKDM4E | |
| SCHEMBL4404890 | 0.88 | TRPM2 (0.49) | L3MBTL1SMN1; SMN2MAPTKMT2AKDM4E | |
| SCHEMBL3076696 | 0.85 | RAB9A (0.53) | L3MBTL1SMN1; SMN2CYP1A2MAPTCYP2C19 | |
| SCHEMBL3076701 | 0.85 | RAB9A (0.53) | L3MBTL1SMN1; SMN2CYP1A2MAPTCYP2C19 | |
| SCHEMBL27372482 | 0.81 | ALDH1A1 (0.57) | L3MBTL1SMN1; SMN2CYP1A2MAPTCYP2C19 | |
| SCHEMBL9147553 | 0.81 | SMN1; SMN2 (0.50) | L3MBTL1SMN1; SMN2MAPTKMT2AKDM4E | |
| SCHEMBL9147560 | 0.81 | SMN1; SMN2 (0.50) | L3MBTL1SMN1; SMN2MAPTKMT2AKDM4E | |
| SCHEMBL27372484 | 0.81 | ALDH1A1 (0.57) | L3MBTL1SMN1; SMN2CYP1A2MAPTCYP2C19 | |
| SCHEMBL9512857 | 0.79 | KDM4E (0.56) | L3MBTL1SMN1; SMN2CYP1A2MAPTCYP2C19 | |
| SCHEMBL10874779 | 0.78 | NPC1 (0.68) | L3MBTL1SMN1; SMN2CYP1A2MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664049-B1 | SYNTHESIS OF PROTECTED PYRROLOBENZODIAZEPINES | SPIROGEN LTD (GB) | 2009-12-23 | — | — | EP | disclosed |
| US-7429658-B2 | Synthesis of protected pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| US-7429658-B2 | Synthesis of protected pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| US-7429658-B2 | Synthesis of protected pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| US-20060264622-A1 | Synthesis of protected pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264622-A1 | Synthesis of protected pyrrolobenzodiazepines | SBDS, DRD2, GRIN2D | L3MBTL1 4334/4885SMN1; SMN2 1882/4885CYP1A2 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.