Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29954391 | 0.84 | VCAM1 (0.67) | VCAM1CYP19A1 | |
| SCHEMBL6330190 | 0.82 | CYP19A1 (0.54) | VCAM1CYP19A1MEN1KMT2AHTT | |
| SCHEMBL7020973 | 0.80 | VCAM1 (0.58) | VCAM1CYP19A1MEN1KMT2AHTT | |
| SCHEMBL348329 | 0.80 | VCAM1 (0.64) | VCAM1CYP19A1MEN1KMT2AHTT | |
| SCHEMBL12265205 | 0.76 | ALDH1A1 (0.47) | CYP19A1MEN1KMT2AHTTLMNA | |
| Dimethylformamide SCHEMBL30939439 | 0.75 | VCAM1 (0.53) | VCAM1KMT2AHTTLMNAKDM4E | |
| SCHEMBL8297742 | 0.74 | TSHR (0.63) | CYP19A1MEN1KMT2AHTTLMNA | |
| SCHEMBL22206136 | 0.74 | CYP19A1 (0.40) | CYP19A1MEN1KMT2AHTTLMNA | |
| SCHEMBL3755068 | 0.74 | ACP1 (0.41) | CYP19A1MEN1KMT2AHTTLMNA | |
| SCHEMBL2016539 | 0.74 | ALDH1A1 (0.46) | CYP19A1HTTTSHRSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317000-B2 | Glucose-dependent insulins | NOVO NORDISK A/S (DK) | 2008-01-08 | — | — | US | claimed |
| US-7316999-B2 | Glucose dependent release of insulin from glucose sensing insulin derivatives | NOVO NORDISK A/S (DK) | 2008-01-08 | — | — | US | disclosed |
| US-7317000-B2 | Glucose-dependent insulins | NOVO NORDISK A/S (DK) | 2008-01-08 | — | — | US | disclosed |
| EP-1453860-A2 | NOVEL GLUCOSE-DEPENDANT INSULINS | NOVO NORDISK A/S (DK) | 2004-09-08 | — | — | EP | disclosed |
| US-20030186846-A1 | Novel glucose-dependent insulins | NOVO NORDISK A/S (DK) | 2003-10-02 | — | — | US | disclosed |
| WO-2003048195-A2 | GLUCOSE DEPENDANT RELEASE OF INSULIN FROM GLUCOSE SENSING INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2003-06-12 | — | — | WO | disclosed |
| EP-1290024-A1 | GLUCOSE DEPENDENT RELEASE OF INSULIN FROM GLUCOSE SENSING INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2003-03-12 | — | — | EP | disclosed |
| US-20020028767-A1 | Glucose dependent release of insulin from glucose sensing insulin derivatives | NOVO NORDISK A/S (DK) | 2002-03-07 | — | — | US | disclosed |
| WO-2001092334-A1 | GLUCOSE DEPENDENT RELEASE OF INSULIN FROM GLUCOSE SENSING INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028767-A1 | Glucose dependent release of insulin from glucose sensing insulin derivatives | GPR119, IRS1, IAPP | VCAM1 2152/4885CYP19A1 1073/4885MEN1 598/4885 |
| US-20030186846-A1 | Novel glucose-dependent insulins | GPR119, IAPP, INSR | VCAM1 2702/4885CYP19A1 585/4885MEN1 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.