Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.52 |
| ▸ | HMGCR | P04035 | 5/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3271017 | 0.89 | PTPN7 (0.40) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL9547918 | 0.87 | PTPN7 (0.43) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL9547952 | 0.82 | — | — | |
| Bicarbonate SCHEMBL15967833 | 0.82 | PTPN7 (0.71) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL30088538 | 0.81 | PTPN7 (0.53) | PTPN7HMGCRRECQLTDP1KDM4E | |
| Bicarbonate SCHEMBL15967786 | 0.80 | PTPN7 (0.75) | PTPN7HMGCRRECQLTDP1KDM4E | |
| Bicarbonate SCHEMBL15967688 | 0.80 | PTPN7 (0.75) | PTPN7HMGCRRECQLTDP1KDM4E | |
| Bicarbonate SCHEMBL15967903 | 0.80 | PTPN7 (0.75) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL30088502 | 0.79 | PTPN7 (0.57) | PTPN7HMGCRRECQLTDP1KDM4E | |
| SCHEMBL3817935 | 0.79 | PTPN7 (0.57) | PTPN7HMGCRRECQLTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030036489-A1 | Consumable composition comprising perfumed particles and article containing the same | THE PROCTER & GAMBLE COMPANY | 2003-02-20 | — | — | US | claimed |
| WO-2002090479-A1 | PERFUMED PARTICLES AND ARTICLES CONTAINING THE SAME | THE PROCTER & GAMBLE COMPANY (US) | 2002-11-14 | — | — | WO | claimed |
| WO-2002090481-A1 | COMPOSITIONS AND ARTICLES FOR EFFECTIVE DEPOSITION OF PERFUME | THE PROCTER & GAMBLE COMPANY (US) | 2002-11-14 | — | — | WO | claimed |
| US-20080221003-A1 | CONSUMER PRODUCTS HAVING VARYING ODOR PATTERNS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080207481-A1 | CONSUMER PRODUCTS HAVING VARYING ODORS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2008-08-28 | — | — | US | disclosed |
| US-20080207476-A1 | PARTICLES CONTAINING PERFUME HAVING IMPROVED FRAGRANCE PROPERTIES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2008-08-28 | — | — | US | disclosed |
| WO-2007128326-A1 | PERFUME DELIVERY SYSTEM FOR CLEANERS | EVONIK GOLDSCHMIDT GMBH (DE) | 2007-11-15 | — | — | WO | disclosed |
| EP-1841850-A1 | PERFUME DELIVERY SYSTEM | Degussa GmbH (DE) | 2007-10-10 | — | — | EP | disclosed |
| EP-1828365-A1 | PERFUME DELIVERY SYSTEM | Degussa GmbH (DE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006079089-A1 | PERFUME DELIVERY SYSTEM | DEGUSSA GMBH (DE) | 2006-07-27 | — | — | WO | disclosed |
| US-20060165740-A1 | Perfume delivery system | GOLDSCHMIDT CHEMICAL CORPORATION (US) | 2006-07-27 | — | — | US | disclosed |
| EP-1383547-A2 | AIR FRESHENING COMPOSITIONS, ARTICLES COMPRISING SAME AND METHODS FOR PREPARING SAME | THE PROCTER & GAMBLE COMPANY (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1383858-A1 | DRYER-ADDED FABRIC SOFTENING ARTICLES AND METHODS | The Procter & Gamble Company (US) | 2004-01-28 | — | — | EP | disclosed |
| US-20030036489-A1 | Consumable composition comprising perfumed particles and article containing the same | THE PROCTER & GAMBLE COMPANY | 2003-02-20 | — | — | US | disclosed |
| US-20030024997-A1 | Air freshening compositions, articles comprising same and methods | THE PROCTER & GAMBLE COMPANY | 2003-02-06 | — | — | US | disclosed |
| US-20030013632-A1 | Dryer-added fabric softening articles and methods | THE PROCTER & GAMBLE COMPANY | 2003-01-16 | — | — | US | disclosed |
| WO-2002090479-A1 | PERFUMED PARTICLES AND ARTICLES CONTAINING THE SAME | THE PROCTER & GAMBLE COMPANY (US) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002089862-A2 | AIR FRESHENING COMPOSITIONS, ARTICLES COMPRISING SAME AND METHODS FOR PREPARING SAME | THE PROCTER & GAMBLE COMPANY (US) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002090480-A1 | DRYER-ADDED FABRIC SOFTENING ARTICLES AND METHODS | THE PROCTER & GAMBLE COMPANY (US) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002090481-A1 | COMPOSITIONS AND ARTICLES FOR EFFECTIVE DEPOSITION OF PERFUME | THE PROCTER & GAMBLE COMPANY (US) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060165740-A1 | Perfume delivery system | CUTA, PEF1, PIGS | PTPN7 3104/4885HMGCR 3986/4885RECQL 2996/4885 |
| US-20030024997-A1 | Air freshening compositions, articles comprising same and methods | PIEZO1, TMEM63A, KIT | PTPN7 4154/4885HMGCR 2843/4885RECQL 365/4885 |
| US-20080207476-A1 | PARTICLES CONTAINING PERFUME HAVING IMPROVED FRAGRANCE PROPERTIES | DSC1, DSG1, PIEZO1 | PTPN7 4176/4885HMGCR 3111/4885RECQL 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.